English  |  正體中文  |  简体中文  |  Post-Print筆數 : 27 |  Items with full text/Total items : 92429/122733 (75%)
Visitors : 26284164      Online Users : 336
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item: http://nccur.lib.nccu.edu.tw/handle/140.119/110180

    Title: N,N-dimethylglycine differentially modulates psychotomimetic and antidepressant-like effects of ketamine in mice
    Authors: 詹銘煥
    Lin, Jen-Cheng;Chan, Ming-Huan;Lee, Mei-Yi;Chen, Yi-Chyan;Chen, Hwei-Hsien
    Contributors: 神科所
    Keywords: Anesthesia;Forced swimming;Glycine;NMDA receptor;Prepulse inhibition
    Date: 2016-11
    Issue Date: 2017-06-05 14:44:47 (UTC+8)
    Abstract: Ketamine, a dissociative anesthetic, produces rapid and sustained antidepressant effects at subanesthtic doses. However, it still inevitably induces psychotomimetic side effects. N,N-dimethylglycine (DMG) is a derivative of the amino acid glycine and is used as a dietary supplement. Recently, DMG has been found acting at glycine binding site of the N-methyl-d-aspartate receptor (NMDAR). As blockade of NMDARs is one of the main mechanisms responsible for the action of ketamine on central nervous system, DMG might modulate the behavioral responses to ketamine. The present study determined the effects of DMG on the ketamine-induced psychotomimetic, anesthetic and antidepressant-like effects in mice. DMG pretreatment reversed the ketamine-induced locomotor hyperactivity and impairment in the rotarod performance, novel location and novel object recognition tests, and prepulse inhibition. In addition, DMG alone exhibited antidepressant-like effects in the forced swim test and produced additive effects when combined with ketamine. However, DMG did not affect ketamine-induced anesthesia. These results reveal that DMG could antagonize ketamine's psychotomimetic effects, yet produce additive antidepressant-like effects with ketamine, suggesting that DMG might have antipsychotic potential and be suitable as an add-on therapy to ketamine for patients with treatment-resistant depression.
    Relation: Prog Neuropsychopharmacol Biol Psychiatry., Vol.71, pp.7-13
    Data Type: article
    DOI 連結: https://doi.org/10.1016/j.pnpbp.2016.06.002
    DOI: 10.1016/j.pnpbp.2016.06.002
    Appears in Collections:[神經科學研究所 ] 期刊論文

    Files in This Item:

    File SizeFormat
    7-13.pdf844KbAdobe PDF268View/Open

    All items in 政大典藏 are protected by copyright, with all rights reserved.

    社群 sharing

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback