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政大機構典藏 > 理學院 > 應用物理研究所 > 期刊論文 > Item 140.119/111409

Please use this identifier to cite or link to this item: https://nccur.lib.nccu.edu.tw/handle/140.119/111409

Title:	Automatic inhibitory function in the human somatosensory and motor cortices: An MEG-MRS study
Authors:	Cheng, Chia-Hsiung;Tsai, Shang-Yueh;Liu, Chia-Yih;Niddam, David M. 蔡尚岳
Contributors:	應物所;心腦中心
Date:	2017
Issue Date:	2017-07-25 15:53:11 (UTC+8)
Abstract:	While the automatic inhibitory function of the human cerebral cortex has been extensively investigated by means of electrophysiological recordings, the corresponding modulating neurochemical mechanisms remain unclear. We aimed to examine whether the primary somatosensory (SI) and primary motor cortical (MI) inhibitory function is associated with endogenous GABA levels. Eighteen young participants received paired-pulse and single-pulse electrical stimulation to the median nerve during magnetoencephalographic recordings. The SI sensory gating (SG), considered as an automatic inhibitory ability, was measured as the amplitude ratio of Stimulus 2 over Stimulus 1, in the paired-pulse paradigm. In addition, stimulus-induced beta activity, considered to originate from MI and also to be related to inhibitory function, was estimated using the single-pulse paradigm. The GABA+ concentration of the sensorimotor cortex was acquired from each subject by using magnetic resonance spectroscopy (MRS). A lower SG ratio in SI was significantly associated with an increased beta power in MI. More importantly, the beta rebound power, but not SI SG ratio, was positively correlated with GABA+ concentration. Our findings show a tight functional relationship between SI and MI during processing of automatic inhibition. GABA+ levels appear to be more closely related to the automatic inhibitory function of MI than SI.
Relation:	Volume 7, Issue 1, 論文編號 4234
Data Type:	article
DOI 連結:	http://dx.doi.org/10.1038/s41598-017-04564-1
DOI:	10.1038/s41598-017-04564-1
Appears in Collections:	[應用物理研究所 ] 期刊論文

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