English  |  正體中文  |  简体中文  |  Post-Print筆數 : 27 |  Items with full text/Total items : 92416/122720 (75%)
Visitors : 26258354      Online Users : 125
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    政大機構典藏 > 理學院 > 心理學系 > 期刊論文 >  Item 140.119/111423
    Please use this identifier to cite or link to this item: http://nccur.lib.nccu.edu.tw/handle/140.119/111423

    Title: Effects of sarcosine and N, N-dimethylglycine on NMDA receptor-mediated excitatory field potentials
    Authors: Chan, Ming-Huan
    Chen, Hwei-Hsien
    Tseng, Yufeng Jane
    Lee, Mei-Yi
    Lin, Yi-Ruu
    Tu, Yi-Shu
    Contributors: 神經科學研究所;心智、大腦與學習研究中心
    Keywords: dimethylglycine;n methyl dextro aspartic acid receptor;sarcosine;agonists;analogs and derivatives;animal;drug effects;Institute for Cancer Research mouse;male;membrane potential;metabolism;mouse;Animals;Male;Membrane Potentials;Mice;Mice, Inbred ICR;Receptors, N-Methyl-D-Aspartate;Sarcosine
    Date: 2017
    Issue Date: 2017-07-27 12:50:57 (UTC+8)
    Abstract: Background: Sarcosine, a glycine transporter type 1 inhibitor and an N-methyl-D-aspartate (NMDA) receptor co-agonist at the glycine binding site, potentiates NMDA receptor function. Structurally similar to sarcosine, N,N-dimethylglycine (DMG) is also N-methyl glycine-derivative amino acid and commonly used as a dietary supplement. The present study compared the effects of sarcosine and DMG on NMDA receptor-mediated excitatory field potentials (EFPs) in mouse medial prefrontal cortex brain slices using a multi-electrode array system. Results: Glycine, sarcosine and DMG alone did not alter the NMDA receptor-mediated EFPs, but in combination with glutamate, glycine and its N-methyl derivatives significantly increased the frequency and amplitude of EFPs. The enhancing effects of glycine analogs in combination with glutamate on EFPs were remarkably reduced by the glycine binding site antagonist 7-chlorokynurenate (7-CK). However, DMG, but not sarcosine, reduced the frequency and amplitude of EFPs elicited by co-application of glutamate plus glycine. D-cycloserine, a partial agonist at the glycine binding site on NMDA receptors, affected EFPs in a similar manner to DMG. Furthermore, DMG, but not sarcosine, reduced the frequencies and amplitudes of EFPs elicited by glutamate plus D-serine, another endogenous ligand for glycine binding site. Conclusions: These findings suggest that sarcosine acts as a full agonist, yet DMG is a partial agonist at glycine binding site of NMDA receptors. The molecular docking analysis indicated that the interactions of glycine, sarcosine, and DMG to NMDA receptors are highly similar, supporting that the glycine binding site of NMDA receptors is a critical target site for sarcosine and DMG. © 2017 The Author(s).
    Relation: Journal of Biomedical Science, 24(1), 論文編號 18
    Data Type: article
    DOI 連結: http://dx.doi.org/10.1186/s12929-016-0314-8
    DOI: 10.1186/s12929-016-0314-8
    Appears in Collections:[心理學系] 期刊論文

    Files in This Item:

    File Description SizeFormat
    s12929-016-0314-8.pdf1934KbAdobe PDF450View/Open

    All items in 政大典藏 are protected by copyright, with all rights reserved.

    社群 sharing

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback