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    Title: Is the sense of agency in schizophrenia influenced by resting-state variation in self-referential regions of the brain?
    Authors: Robinson, Jeffrey D.
    Wagner, Nils Frederic
    Northoff, Georg
    Contributors: 心智、大腦與學習研究中心
    Keywords: Article;brain region;conceptual framework;default mode network;electroencephalogram;human;neurobiology;neuroimaging;neuroscience;phenomenology;priority journal;resting state network;schizophrenia;stimulation;theory;brain;pathophysiology;schizophrenia;self concept;Brain;Humans;Schizophrenia;Self Concept
    Date: 2016-03
    Issue Date: 2017-08-31 11:20:57 (UTC+8)
    Abstract: Schizophrenia is a disturbance of the self, of which the attribution of agency is a major component. In this article, we review current theories of the Sense of Agency, their relevance to schizophrenia, and propose a novel framework for future research. We explore some of the models of agency, in which both bottom-up and top-down processes are implicated in the genesis of agency. We further this line of inquiry by suggesting that ongoing neurological activity (the brain's resting state) in self-referential regions of the brain can provide a deeper level of influence beyond what the current models capture. Based on neuroimaging studies, we suggest that aberrant activity in regions such as the default mode network of individuals with schizophrenia can lead to a misattribution of internally/externally generated stimuli. This can result in symptoms such as thought insertion and delusions of control. Consequently, neuroimaging can contribute to a more comprehensive conceptualization and measurement of agency and potential treatment implications.
    Relation: Schizophrenia Bulletin, 42(2), 270-276
    Data Type: article
    DOI 連結: http://dx.doi.org/10.1093/schbul/sbv102
    DOI: 10.1093/schbul/sbv102
    Appears in Collections:[心智‧大腦與學習研究中心 ] 期刊論文

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