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    题名: Frontal Assessment Battery as a Useful Tool to Differentiate Mild Cognitive Impairment due to Subcortical Ischemic Vascular Disease from Alzheimer Disease
    作者: 楊啟正
    Hsu, Y.-H.
    Huang, C.-F.
    Lo, C.-P.
    Wang, T.-L.
    Yang, C.-C.
    Tu, M.-C
    贡献者: 心理系
    关键词: Dementia;Neuropsychological tests;Magnetic resonance imaging;White matter hyperintensities;Screening test;Differential diagnosis;Verbal fluency
    日期: 2016-05
    上传时间: 2017-09-06 16:29:39 (UTC+8)
    摘要: Background: Prominent executive dysfunction can differentiate vascular dementia from Alzheimer disease (AD). However, it is unclear whether the Frontal Assessment Battery (FAB) screening tool can differentiate subcortical ischemic vascular disease (SIVD) from AD at the pre-dementia stage. In addition, the neural correlates of FAB performance have yet to be clarified. Methods: Patients with mild cognitive impairment (MCI) due to SIVD (MCI-V), MCI due to AD (MCI-A), and demographically matched controls completed the Mini-Mental State Examination, Taiwanese FAB (TFAB), Category Fluency, and Chinese Version of the Verbal Learning Test, and underwent magnetic resonance imaging. White matter hyperintensities were rated according to the Scheltens scale. Results: TFAB total scale and its Orthographical Fluency subtest were the only measures that could differentiate MCI-V from MCI-A. Discriminative analysis showed that Orthographical Fluency scores successfully identified 73.2% of the cases with MCI-V, with 85.0% sensitivity. Orthographical Fluency scores were specifically associated with lesion load within frontal periventricular, frontal deep white matter, and basal ganglia regions. Conclusion: The TFAB, and especially its 1-min Orthographical Fluency subtest, is a useful screening procedure to differentiate MCI due to SIVD from MCI due to AD. The discriminative ability is probably due to frontosubcortical white matter pathologies disproportionately involved in the two disease entities.
    關聯: Dementia and Geriatric Disorders, Vol.42, No.5-6, pp.331-341
    数据类型: article
    DOI 連結: https://doi.org/10.1159/000452762
    DOI: 10.1159/000452762
    显示于类别:[心理學系] 期刊論文

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