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政大典藏 > College of Science > Department of Psychology > Periodical Articles > Item 140.119/112534

Please use this identifier to cite or link to this item: https://nccur.lib.nccu.edu.tw/handle/140.119/112534

Title:	Microstructural integrity of cerebral fiber tracts in hereditary spastic paraparesis with SPG11 mutation.
Authors:	楊啟正 Pan, M.-K. Huang, S.-C. Lo, Y.-C. Yang, Chih-Chao Cheng, T.-W. Yang, Chi-Cheng Hua, M.-S. Tseng, M.-J. Lee and W.-Y.I.
Contributors:	心理系
Date:	2013-05
Issue Date:	2017-09-06 16:30:01 (UTC+8)
Abstract:	BACKGROUND AND PURPOSE: ARHSP-TCC is characterized by progressive leg spasticity, ataxia, and cognitive dysfunction. Although mutations in the human SPG11 gene were identified as responsible for ARHSP-TCC, the cerebral fiber integrity has not been assessed systemically. The objective of this study was to assess cerebral fiber integrity and its clinical significance in patients with ARHSP-TCC. MATERIALS AND METHODS: Five patients from 2 families who were clinically and genetically confirmed to have ARHSP-TCC were examined by neuropsychological evaluation and DSI of the brain. We performed voxel-based GFA analysis for global white matter evaluation, tractography-based analysis for tract-to-tract comparisons, and tract-specific analysis of the CST to evaluate microstructural integrity along the axonal direction.
Relation:	American Journal of Nuclear Radiology, Vol.34, No.5, pp.990-996
Data Type:	article
DOI link:	https://doi.org/10.3174/ajnr.A3330
DOI:	10.3174/ajnr.A3330
Appears in Collections:	[Department of Psychology] Periodical Articles

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