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    题名: Antipsychotic reexposure and recurrent pneumonia in schizophrenia: A nested case-control study
    作者: 潘俊宏
    Hung, Galen Chin Lun
    Liu, Hsing Cheng
    Yang, Shu Yu
    Pan, Chun Hung
    Liao, Ya Tang
    Chen, Chiao Chicy
    Kuo, Chian Jue
    贡献者: 心理系
    关键词: amisulpride;antidepressant agent;aripiprazole;benzodiazepine;chlorpromazine;clozapine;flupentixol;haloperidol;mood stabilizer;neuroleptic agent;olanzapine;quetiapine;risperidone;sulpiride;zotepine;clozapine;neuroleptic agent;adult;Article;case control study;cohort analysis;controlled study;disease association;disease classification;drug efficacy;drug reexposure;drug safety;female;high risk patient;human;major clinical study;male;pneumonia;priority journal;propensity score;recurrent disease;recurrent pneumonia;recurrent pneumonia;schizophrenia;Taiwan;treatment duration;adolescent;aged;chemically induced;complication;dose response;factual database;middle aged;pneumonia;risk factor;schizophrenia;sexual development;young adult;Adolescent;Adult;Aged;Antipsychotic Agents;Case-Control Studies;Clozapine;Databases, Factual;Dose-Response Relationship, Drug;Female;Humans;Male;Middle Aged;Pneumonia;Recurrence;Risk Factors;Schizophrenia;Sex Characteristics;Young Adult
    日期: 2016-01
    上传时间: 2017-09-15 15:19:34 (UTC+8)
    摘要: Objective: Few studies have used systematic datasets to assess the safety of antipsychotic rechallenge after an adverse event. This nested case-control study estimated the risk for recurrent pneumonia after reexposure to antipsychotic treatment. Method: In a nationwide schizophrenia (ICD-9-CM code 295) cohort (derived from the National Health Insurance Research Database in Taiwan) who were hospitalized for pneumonia (ICD-9-CM codes 480-486, 507) between 2000 and 2008 (N = 2,201), we identified 494 subjects that developed recurrent pneumonia after a baseline pneumonia episode. Based on risk-set sampling in a 1:3 ratio, 1,438 matched controls were selected from the cohort. Exposures to antipsychotics were categorized by type, duration, and defined daily dose. Using propensity score-adjusted analysis, we assessed individual antipsychotics for the risk of recurrent pneumonia; we furthermore assessed the effect of reexposure to these antipsychotics on the risk of recurrent pneumonia. Results: Of the antipsychotics studied, current use of clozapine was the only one associated with a clear dose-dependent increase in the risk for recurrent pneumonia (adjusted risk ratio = 1.40, P =.024). Intriguingly, patients reexposed to clozapine had a higher risk for recurrent pneumonia (adjusted risk ratio = 1.99, P =.023) than those receiving clozapine only prior to the baseline pneumonia, and this risk was associated with gender. Women reexposed to clozapine were more susceptible to recurrent pneumonia (adjusted risk ratio = 4.93, P =.050). Conclusions: In patients experiencing pneumonia while undergoing clozapine treatment, physicians should carefully consider the increased risk of pneumonia recurrence when clozapine is reintroduced. Future studies should try to quantify the risk of other medical conditions associated with clozapine reexposure.
    關聯: Journal of Clinical Psychiatry, 77(1), 60-66
    数据类型: article
    DOI 連結: http://dx.doi.org/10.4088/JCP.14m09301
    DOI: 10.4088/JCP.14m09301
    显示于类别:[心理學系] 期刊論文

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