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    题名: 利用波動聚集方法探討老化對靜息態腦網路與心率變異度之影響
    作者: 蕭又新
    贡献者: 應用物理研究所
    关键词: 老化;功能性連結;腦島;中樞自主腦網路;靜息態
    aging;functional connectivity;insula;central autonomic network;resting state
    日期: 2015
    上传时间: 2017-12-26 17:49:09 (UTC+8)
    摘要: 本研究藉由種子體素關聯性分析這些中樞自主腦網路的核心腦區，我們的結果顯示這些所屬於中樞自主腦網路下的交感和副交感網路是潛在地存在於靜息態大腦中，其中自發性血氧濃度相依訊號的正反相關現象將其劃分為交感和副交感相關的網路。進一步的驗證指出與年齡相關的退化發生在右前腦島與邊緣整合皮質的功能性聯結，而在中樞自主腦網路中這些老化而降低的功能性聯結，很可能與老年人在減弱的記憶功能和調節穩定的身體狀態有所相關。
    Autonomic nervous system (ANS) plays a critical role of quick reactions in the adaptation to the environment change, which constantly modulates visceral reflex function for a stable bodily state of task preparedness. More recently, the resting-state functional connectivity (rsFC) without subjects performing a specific cognitive task provides an alternative tool for tracking the potential neural substrates but less is known in the spontaneous neuronal activity of central autonomic network (CAN), where the CAN components encompass a sympathetic/parasympathetic network and anti-correlations with each other. We found the evidence of aging that is related to weak coupling of CAN components between right anterior insula (aINS.R) and limbic regions, which may affect the regulation of autonomic control and more specifically with memory and emotion function. Our study also provided insights about the central processing map of autonomic functions in the resting brain.
    關聯: 執行起迄：2015/08/01~2016/07/31
    104-2112-M-004-001
    数据类型: report
    显示于类别:[資訊科學系] 國科會研究計畫

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    104-2112-M-004-001.pdf5589KbAdobe PDF2699检视/开启


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