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    题名: Valproic acid inhibits glioblastoma multiforme cell growth via paraoxonase 2 expression.
    作者: 蕭勝煌
    Tseng, Jen-Ho
    Chen, Cheng-Yi
    Chen, Pei-Chun
    Hsiao, Sheng-Huang
    Fan, Chi-Chen
    Liang, Yu-Chih
    Chen, Chie-Pein
    贡献者: 心理系
    日期: 2017-02
    上传时间: 2018-01-15 11:39:39 (UTC+8)
    摘要: We studied the potential mechanisms of valproic acid (VPA) in the treatment of glioblastoma multiforme (GBM). Using the human U87, GBM8401, and DBTRG-05MG GBM-derived cell lines, VPA at concentrations of 5 to 20 mM induced G2/M cell cycle arrest and increased the production of reactive oxygen species (ROS). Stress-related molecules such as paraoxonase 2 (PON2), cyclin B1, cdc2, and Bcl-xL were downregulated, but p27, p21 and Bim were upregulated by VPA treatment. VPA response element on the PON2 promoter was localized at position -400/-1. PON2 protein expression was increased in GBM cells compared with normal brain tissue and there was a negative correlation between the expression of PON2 and Bim. These findings were confirmed by the public Bredel GBM microarray (Gene Expression Omnibus accession: GSE2223) and the Cancer Genome Atlas GBM microarray datasets. Overexpression of PON2 in GBM cells significantly decreased intracellular ROS levels, and PON2 expression was decreased after VPA stimulation compared with controls. Bim expression was significantly induced by VPA in GBM cells with PON2 silencing. These observations were further shown in the subcutaneous GBM8401 cell xenograft of BALB/c nude mice. Our results suggest that VPA reduces PON2 expression in GBM cells, which in turn increases ROS production and induces Bim production that inhibits cancer progression via the PON2-Bim cascade.
    關聯: Oncotarget , 2017; 8:14666-14679
    数据类型: article
    DOI 連結: http://dx.doi.org/10.18632/oncotarget.14716
    DOI: 10.18632/oncotarget.14716
    显示于类别:[心理學系] 期刊論文

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