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    Please use this identifier to cite or link to this item: http://nccur.lib.nccu.edu.tw/handle/140.119/120071


    Title: Strong Circadian Rhythms in the Choroid Plexus: Implications for Sleep-Independent Brain Metabolite Clearance
    Authors: Myung, Jihwan;Wu, Dean;Simonneaux, Valérie;Lane, Timothy Joseph
    藍亭
    Lane, Timothy Joseph
    Contributors: 心腦中心
    Keywords: Choroid plexus;circadian clock;metabolite clearance;neurodegenerative disease
    Date: 2018
    Issue Date: 2018-09-11 18:34:10 (UTC+8)
    Abstract: Cerebrospinal fluid (CSF) is a fluidic part of the brain’s microenvironment that isolates the brain from the rest of the body. CSF dilutes metabolites from neuronal activities and removes them from the brain. Its production and resorption are regulated dynamically and are central to maintaining brain homeostasis. We discovered that the major CSF source, the choroid plexus (CP), harbors the brain’s strongest circadian clock. Here, we consider some implications of the CP circadian clock for metabolite clearance in the brain. If the circadian clock contributes to timed production of the CSF, its synchronization with sleep timing can maximize clearance efficiency and help prevent neurodegenerative diseases such as Alzheimer’s disease.
    Relation: Journal of Experimental Neuroscience, Vol.12
    Data Type: article
    DOI 連結: https://doi.org/10.1177/1179069518783762
    DOI: 10.1177/1179069518783762
    Appears in Collections:[心智‧大腦與學習研究中心 ] 期刊論文

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