English  |  正體中文  |  简体中文  |  Items with full text/Total items : 88284/117783 (75%)
Visitors : 23395320      Online Users : 162
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item: http://nccur.lib.nccu.edu.tw/handle/140.119/120972


    Title: Long-lived Indy induces reduced mitochondrial reactive oxygen species production and oxidative damage
    Authors: Neretti, Nicola;Wang, Pei-Yu;Brodsky, Alexander S.;Nyguyen, Hieu H.;White, Kevin P.;Rogina, Blanka;Helfand, Stephen L.
    王培育
    Wang, Pei-Yu
    Contributors: 神科所
    Keywords: electron transport chain;mitochondria;oxidative phosphorylation;Drosophila;aging
    Date: 2009-02
    Issue Date: 2018-11-21 16:23:04 (UTC+8)
    Abstract: Decreased Indy activity extends lifespan in D. melanogaster without significant reduction in fecundity, metabolic rate, or locomotion. To understand the underlying mechanisms leading to lifespan extension in this mutant strain, we compared the genome-wide gene expression changes in the head and thorax of adult Indy mutant with control flies over the course of their lifespan. A signature enrichment analysis of metabolic and signaling pathways revealed that expression levels of genes in the oxidative phosphorylation pathway are significantly lower in Indy starting at day 20. We confirmed experimentally that complexes I and III of the electron transport chain have lower enzyme activity in Indy long-lived flies by Day 20 and predicted that reactive oxygen species (ROS) production in mitochondria could be reduced. Consistently, we found that both ROS production and protein damage are reduced in Indy with respect to control. However, we did not detect significant differences in total ATP, a phenotype that could be explained by our finding of a higher mitochondrial density in Indy mutants. Thus, one potential mechanism by which Indy mutants extend life span could be through an alteration in mitochondrial physiology leading to an increased efficiency in the ATP/ROS ratio.
    Relation: Proceedings of the National Academy of Sciences of the United States of America, Vol.106, No.7, pp.2277-2282
    PMID: 19164521
    Data Type: article
    DOI 連結: https://doi.org/10.1073/pnas.0812484106
    DOI: 10.1073/pnas.0812484106
    Appears in Collections:[神經科學研究所 ] 期刊論文

    Files in This Item:

    File Description SizeFormat
    zpq2277.pdf817KbAdobe PDF100View/Open


    All items in 政大典藏 are protected by copyright, with all rights reserved.


    社群 sharing

    著作權政策宣告
    1.本網站之數位內容為國立政治大學所收錄之機構典藏,無償提供學術研究與公眾教育等公益性使用,惟仍請適度,合理使用本網站之內容,以尊重著作權人之權益。商業上之利用,則請先取得著作權人之授權。
    2.本網站之製作,已盡力防止侵害著作權人之權益,如仍發現本網站之數位內容有侵害著作權人權益情事者,請權利人通知本網站維護人員(nccur@nccu.edu.tw),維護人員將立即採取移除該數位著作等補救措施。
    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback