English  |  正體中文  |  简体中文  |  Items with full text/Total items : 88284/117783 (75%)
Visitors : 23395317      Online Users : 160
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    Please use this identifier to cite or link to this item: http://nccur.lib.nccu.edu.tw/handle/140.119/120973


    Title: Mullerian inhibiting substance acts as a motor neuron survival factor in vitro
    Authors: Wang, Pei-Yu;Koishi, Kyoko;McGeachie, Andrew B.;Kimber, Michael;MacLaughlin, David T.;Donahoe, Patricia K.;McLennan, Ian S.
    王培育
    Wang, Pei-Yu
    Contributors: 神科所
    Date: 2005-11
    Issue Date: 2018-11-21 16:23:26 (UTC+8)
    Abstract: The survival of motor neurons is controlled by multiple factors that regulate different aspects of their physiology. The identification of these factors is important because of their relationship to motor neuron disease. We investigate here whether Mullerian Inhibiting Substance (MIS) is a motor neuron survival factor. We find that motor neurons from adult mice synthesize MIS and express its receptors, suggesting that mature motor neurons use MIS in an autocrine fashion or as a way to communicate with each other. MIS was observed to support the survival and differentiation of embryonic motor neurons in vitro. During development, male-specific MIS may have a hormone effect because the blood-brain barrier has yet to form, raising the possibility that MIS participates in generating sex-specific differences in motor neurons.
    Relation: Proceedings of the National Academy of Sciences of the United States of America, Vol.102, No.45, pp.16421-16425
    PMID: 16260730
    Data Type: article
    DOI 連結: https://doi.org/10.1073/pnas.0508304102
    DOI: 10.1073/pnas.0508304102
    Appears in Collections:[神經科學研究所 ] 期刊論文

    Files in This Item:

    File Description SizeFormat
    pnas-0508304102.pdf398KbAdobe PDF76View/Open


    All items in 政大典藏 are protected by copyright, with all rights reserved.


    社群 sharing

    著作權政策宣告
    1.本網站之數位內容為國立政治大學所收錄之機構典藏,無償提供學術研究與公眾教育等公益性使用,惟仍請適度,合理使用本網站之內容,以尊重著作權人之權益。商業上之利用,則請先取得著作權人之授權。
    2.本網站之製作,已盡力防止侵害著作權人之權益,如仍發現本網站之數位內容有侵害著作權人權益情事者,請權利人通知本網站維護人員(nccur@nccu.edu.tw),維護人員將立即採取移除該數位著作等補救措施。
    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback