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    Please use this identifier to cite or link to this item: http://nccur.lib.nccu.edu.tw/handle/140.119/120974

    Title: Mullerian Inhibiting Substance contributes to sex-linked biases in the brain and behavior
    Authors: Wang, Pei-Yu;Protheroe, Anna;Clarkson, Andrew N.;Imhoff, Floriane;Koishi, Kyoko;McLennan, Ian S.
    Wang, Pei-Yu
    Contributors: 神科所
    Keywords: anti-Müllerian hormone;exploratory behavior;motor neuron;sexual dimorphism
    Date: 2009-04
    Issue Date: 2018-11-21 16:24:01 (UTC+8)
    Abstract: Many behavioral traits and most brain disorders are common to males and females but are more evident in one sex than the other. The control of these subtle sex-linked biases is largely unstudied and has been presumed to mirror that of the highly dimorphic reproductive nuclei. Sexual dimorphism in the reproductive tract is a product of Müllerian inhibiting substance (MIS), as well as the sex steroids. Males with a genetic deficiency in MIS signaling are sexually males, leading to the presumption that MIS is not a neural regulator. We challenge this presumption by reporting that most immature neurons in mice express the MIS-specific receptor (MISRII) and that male Mis−/− and Misrii−/− mice exhibit subtle feminization of their spinal motor neurons and of their exploratory behavior. Consequently, MIS may be a broad regulator of the subtle sex-linked biases in the nervous system.
    Relation: Proceedings of the National Academy of Sciences of the United States of America, Vol.106, No.17, pp.7203-7208
    PMID: 19359476
    Data Type: article
    DOI 連結: https://doi.org/10.1073/pnas.0902253106
    DOI: 10.1073/pnas.0902253106
    Appears in Collections:[神經科學研究所 ] 期刊論文

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