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    題名: Mullerian Inhibiting Substance contributes to sex-linked biases in the brain and behavior
    作者: Wang, Pei-Yu;Protheroe, Anna;Clarkson, Andrew N.;Imhoff, Floriane;Koishi, Kyoko;McLennan, Ian S.
    王培育
    Wang, Pei-Yu
    貢獻者: 神科所
    關鍵詞: anti-Müllerian hormone;exploratory behavior;motor neuron;sexual dimorphism
    日期: 2009-04
    上傳時間: 2018-11-21 16:24:01 (UTC+8)
    摘要: Many behavioral traits and most brain disorders are common to males and females but are more evident in one sex than the other. The control of these subtle sex-linked biases is largely unstudied and has been presumed to mirror that of the highly dimorphic reproductive nuclei. Sexual dimorphism in the reproductive tract is a product of Müllerian inhibiting substance (MIS), as well as the sex steroids. Males with a genetic deficiency in MIS signaling are sexually males, leading to the presumption that MIS is not a neural regulator. We challenge this presumption by reporting that most immature neurons in mice express the MIS-specific receptor (MISRII) and that male Mis−/− and Misrii−/− mice exhibit subtle feminization of their spinal motor neurons and of their exploratory behavior. Consequently, MIS may be a broad regulator of the subtle sex-linked biases in the nervous system.
    關聯: Proceedings of the National Academy of Sciences of the United States of America, Vol.106, No.17, pp.7203-7208
    PMID: 19359476
    資料類型: article
    DOI 連結: https://doi.org/10.1073/pnas.0902253106
    DOI: 10.1073/pnas.0902253106
    顯示於類別:[神經科學研究所 ] 期刊論文

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