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| Title: | Differential inhibitory effects of resveratrol on excitotoxicity and synaptic plasticity: involvement of NMDA receptor subtypes |
| Authors: | 詹銘煥
Chan, Ming-Huan
Hsieh, Chung-Pin
Chang, Wei-Tang
Chen, Linyi
Chen, Hwei-Hsien |
| Contributors: | 神科所 |
| Date: | 2021-07 |
| Issue Date: | 2021-10-27 10:57:07 (UTC+8) |
| Abstract: | Objectives: The neuroprotective effects of resveratrol against excitatory neurotoxicity have been associated with N-methyl-D-aspartate receptor (NMDAR) inhibition. This study examined the differential inhibitory effects of resveratrol on NMDAR-mediated responses in neuronal cells with different NMDAR subtype composition. Methods: The effects of resveratrol on NMDA-induced cell death and calcium influx in immature and mature rat primary cortical neurons were determined and compared. Moreover, the potencies and efficacies of resveratrol to inhibit NR1/NR2A, NR1/NR2B, NR1/NR2C, and NR1/NR2D NMDAR expressed in HEK 293 cells were evaluated. Results: Resveratrol significantly attenuated NMDA-induced cell death in mature neurons, but not in immature neurons. Resveratrol also concentration-dependently reduced NMDA-induced calcium influx among all NMDAR subtypes, but displayed NR2 subunit selectivity, with a potency rank order of NR2B = NR2D > NR2A = NR2C and an efficacy rank order of NR2B = NR2C > NR2A = NR2D. Data show the stronger inhibitory effects of resveratrol on NR1/NR2B than other subtypes. Moreover, resveratrol did not affect hippocampal long-term potentiation (LTP), but impaired long-term depression (LTD). Discussion: These findings reveal the specific NMDAR modulating profile of resveratrol, providing further insight into potential mechanisms underlying the protective effects of resveratrol on neurological disorders. |
| Relation: | Nutritional Neuroscience, Vol.24, No.6, pp.443-458 |
| Data Type: | article |
| DOI 連結: | https://doi.org/10.1080/1028415X.2019.1641995 |
| DOI: | 10.1080/1028415X.2019.1641995 |
| Appears in Collections: | [神經科學研究所 ] 期刊論文
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