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| Title: | Betaine supplementation to rats alleviates disturbances induced by high-fat diet: pleiotropic effects in model of type 2 diabetes |
| Authors: | 詹銘煥
Chan, Ming-Huan
Szkudelska, K.;Okulicz, M.;Jasaszwili, M.;Lukomska, A.;Malek, E.;Shah, M.;Sunder, S .;Szkudelski, T. |
| Contributors: | 神科所 |
| Keywords: | betaine;diabetes;leptinemia;lipolysis;liver;skeletal muscle;N-methyl D-aspartate receptors;hippocampus;cerebral cortex |
| Date: | 2021-10 |
| Issue Date: | 2022-10-20 16:34:55 (UTC+8) |
| Abstract: | Betaine is a biologically active compound exerting beneficial effects in the organism, however, the exact mechanisms underlying its action are not fully elucidated. The present study aimed to explore, whether betaine alleviates disorders induced by feeding rats a high-fat diet (HFD). Rats were divided into 3 groups: control, fed an HFD and fed an HFD and receiving betaine (2% water solution for 8 weeks). Betaine improved glucose tolerance, decreased blood levels of non-esterified fatty acids and prevented lipid accumulation in the skeletal muscle of rats on an HFD. Betaine reduced activities of blood alanine aminotransferase, blood levels of bilirubin and hepatic lipid content. Expression of fatty acid synthase in the liver and the skeletal muscle was decreased in response to feeding an HFD, and this effect was deepened by betaine in the muscle tissue. Hepatic and muscular expression of genes related to insulin signaling were unchanged in HFD-fed rats. Lipolysis stimulated by epinephrine (an adrenergic receptor agonist), forskolin (an activator of adenylate cyclase), dibutyryl-cAMP (an activator of protein kinase A) and DPCPX (an adenosine A1 receptor antagonist) was diminished in the adipocytes of rats fed an HFD, however, this effect was alleviated by betaine. Moreover, blood leptin levels in HFD-fed rats were elevated, whereas leptinemia have normalized by betaine supplementation. Betaine prevented the increase in expression of N-methyl D-aspartate receptors in the hippocampus and in the cerebral cortex. These results indicate that betaine positively affects the insulin-sensitive tissues: liver (hepatoprotective effects), skeletal muscle (reduced lipid accumulation) and adipose tissue (a rise in lipolysis), which is associated with improved insulin sensitivity. Betaine-induced prevention of hyperleptinemia indicates restoration of leptin action, and changes in the brain reveal neuroprotective properties. Our results show that betaine induces positive changes in HFD-fed rats, its action is pleiotropic and involves different tissues. |
| Relation: | Journal of Physiology and Pharmacology, Vol.72, No.5, pp.763-775 |
| Data Type: | article |
| DOI 連結: | https://doi.org/10.26402/jpp.2021.5.11 |
| DOI: | 10.26402/jpp.2021.5.11 |
| Appears in Collections: | [神經科學研究所 ] 期刊論文
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