政大機構典藏-National Chengchi University Institutional Repository(NCCUR):Item 140.119/19804

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题名:	Place conditioning and neurochemical responses elicited by the aftereffect of acute stressor exposure involving an elevated stand
作者:	Shen, Ying-Ling;Chen, Jin-Chung;Liao, Ruey-Ming;廖瑞銘
贡献者:	國立政治大學心理學系
关键词:	Inescapable stress;Dopamine;DOPAC;Medial prefrontal cortex;Nucleus accumbens;HPLC
日期:	2011
上传时间:	2008-12-29 15:33:42 (UTC+8)
摘要:	Acute exposure to an elevated stand has been used as an inescapable mild stressor for rats. The present study examined the effects of this stressor using a place conditioning behavioral test and neurochemical assays of dopamine and its metabolite, 3,4-dihydroxyphenylacetic acid (DOPAC), in the medial prefrontal cortex and nucleus accumbens. The behavioral data showed that a conditioned place preference was formed as an aftereffect of the elevated stand stressor. In a separate experiment, neurochemical assay showed an immediate increase of dopamine in the nucleus accumbens after 30min exposure to the elevated stand stressor. In addition, the DOPAC content in the nucleus accumbens was significantly increased at 30min after this stressor. No significant change in dopamine or DOPAC levels in the medial prefrontal cortex was detected for up to 60min after stressor manipulation. These results suggest that an increase in dopamine activity in the nucleus accumbens is involved in the development of conditioned place preference elicited by the aftereffects of the elevated stand stressor.
關聯:	Neuroscience Letters, 504, 156-159
数据类型:	article
DOI 連結:	http://dx.doi.org/10.1016/j.neulet.2011.09.022
DOI:	10.1016/j.neulet.2011.09.022
显示于类别:	[心理學系] 期刊論文

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