English  |  正體中文  |  简体中文  |  Post-Print筆數 : 11 |  Items with full text/Total items : 88657/118248 (75%)
Visitors : 23502557      Online Users : 522
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    政大機構典藏 > 理學院 > 心理學系 > 期刊論文 >  Item 140.119/19810
    Please use this identifier to cite or link to this item: http://nccur.lib.nccu.edu.tw/handle/140.119/19810


    Title: Differential Effects of Lesions in the Subareas of Medial Prefrontal Cortex on the Development of Behavioral Sensitization to Amphetamine: Role of Environmental Context
    Authors: Liao, Ruey-Ming
    廖瑞銘
    Lin, Hui-Liu
    Contributors: 國立政治大學心理學系
    Keywords: locomotor sensitization;environmental context;psychostimulants;ibotenate lesion;rat
    Date: 2008-12
    Issue Date: 2008-12-29 15:34:01 (UTC+8)
    Abstract: Based on the notion of the heterogeneity of the medial prefrontal cortex (mPFC), the effects of lesions of the dorsal and ventral subareas of mPFC were examined on the development of behavioral sensitization induced by d-amphetamine (AMP). The first part of this study determined behavioral sensitization to AMP by the use of the rat with intermittent repeated AMP administrations in three types of environmental context including an infrared locomotor activity test-box, the home cage, and a novel third place. In experimental groups, each subject was initially injected with AMP of 0.5 mg/kg as the pretest treatment and then received seven injections of AMP (1 mg/kg) every other day in the context where it was assigned. Following two days of withdrawal, the subject was challenged by AMP of 0.5 mg/kg as the post-test treatment. Behavioral sensitization to AMP on the locomotor activity was determined by the difference between pre- and post-test. The results showed that the most profound locomotor sensitization to AMP appeared in the test box group. A less but significant degree of locomotor sensitization to AMP was observed for the home cage group. A trend of locomotor sensitization to AMP observed in the novel third place group was not statistically confirmed. In the second part of experiment, we then investigated the effects of lesions in the dorsal and ventral mPFC subareas on the development of locomotor sensitization to AMP in the test box and home cage. Results showed that locomotor sensitization was significantly appeared in every sham-operated control group tested in either test box or home cage. Lesions of ventral mPFC significantly inhibited the development of locomotor sensitization to AMP in test box, but not in home cage. Lesions of dorsal mPFC failed to affect AMP locomotor sensitization developed in either test box or home cage. These data indicate that the heterogeneous functions of mPFC subareas involved in the development of behavioral sensitization to AMP are dependent on different contexts applied for repeated intermittent drug administration.
    Relation: Chinese Journal of Physiology, 51(6), 394-401
    Data Type: article
    Appears in Collections:[心理學系] 期刊論文

    Files in This Item:

    File Description SizeFormat
    51-6-9.pdf741KbAdobe PDF851View/Open


    All items in 政大典藏 are protected by copyright, with all rights reserved.


    社群 sharing

    著作權政策宣告
    1.本網站之數位內容為國立政治大學所收錄之機構典藏,無償提供學術研究與公眾教育等公益性使用,惟仍請適度,合理使用本網站之內容,以尊重著作權人之權益。商業上之利用,則請先取得著作權人之授權。
    2.本網站之製作,已盡力防止侵害著作權人之權益,如仍發現本網站之數位內容有侵害著作權人權益情事者,請權利人通知本網站維護人員(nccur@nccu.edu.tw),維護人員將立即採取移除該數位著作等補救措施。
    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback