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    题名: Dopamine Receptor Antagonists Reverse Amphetamine-Induced Behavioral Alteration on a Differential Reinforcement for Low-rate (DRL) Operant Task in the Rat
    作者: Cheng, Ruey-Kuang
    Liao, Ruey-Ming
    廖瑞銘
    贡献者: 國立政治大學心理學系
    关键词: D1 and D2 receptors;IRT analysis;psychostimulant;raclopride;SCH23390;timing behavior
    日期: 2007-04
    上传时间: 2008-12-29 15:34:16 (UTC+8)
    摘要: Previous studies have shown that amphetamine significantly alters operant responding on the
    behavior maintained on a schedule of differential reinforcement of low-rate (DRL). As such, behavioral
    deficiency of DRL responding has been observed by the drug-induced increase of non-reinforced
    responses and a leftward shift of inter-response time (IRT) curve on DRL responding in the rat.
    However, the neurochemical basis for amphetamine-induced DRL behavioral alternations remain to be
    elucidated. The present study was then designed to examine whether the effects of amphetamine were
    dependent on dopamine-subtyped receptors, this was carried out by the co-administration of the
    selective D1 and D2 receptor antagonists, SCH23390 and raclopride respectively. Rats were first trained
    to perform on DRL 10-sec task and then divided into four groups, which received separate types of
    double injections before the behavioral session. The four groups were the saline control group, the
    amphetamine alone group, the dopamine antagonist alone group, and the combination amphetamine and
    dopamine antagonist group. The saline control group performed DRL responding in an efficient manner
    with a major index for the peak time of the IRT curve, which was fairly localized within the 10-sec bin
    throughout the test phase. The subjects injected with amphetamine (1 mg/kg) significantly shortened
    IRT that led to a leftward shift of IRT curve, which was further revealed by a decreased peak time
    without significant effectiveness on the peak rate and burst response. Even though the group given
    SCH23390 or raclopride alone showed profound disruption on DRL behavior by flattening the IRT
    curve, the co-administration of amphetamine with SCH23390 or raclopride reversed the aforementioned
    amphetamine-induced behavioral deficiency on DRL task. Together, these results suggest that the
    dopamine D1 and D2 receptors are involved and important to the temporal regulation of DRL response
    under psychostimulant drug treatment. Furthermore, this highlights the involvement of the brain
    dopamine systems in the temporal regulation of DRL behavior performance.
    關聯: Chinese Journal of Physiology, 50(2) , 77-88
    数据类型: article
    显示于类别:[心理學系] 期刊論文

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