This article attempts to explore the post-Cold War international system in which regional orders intermingle their influence. It pays special attention to regional conflicts in East Asia in the new era and what roles global powers could play to maintain regional stability. I will first examine the characteristics of the new global order after the end of the bipolarity. I will then focus on American foreign policy in the new international system in the context of its dealing with major global events that have strategic implications for its relations with other major global powers. As to discussions of regional orders, this article focuses on East Asia, where conflicts between states have not evaporated despite the relaxation of the global Cold War confrontation. What makes this area special is the involvements of many great powers and less-powerful nations that could somehow easily manipulate the seniors into the conflicts to their favour. While the regional order in East Asia is being shaped by the post- Cold War international order, the region’s peace and conflicts will in turn significantly influence global order. Finally, I will argue that dealing with problems in East Asia should acquire involvements of powers that would give necessary momentum to the existing participants to solve conflicts by the means of multilateralism. The European Union (EU) is often forgotten for its role in contributing to world order, and the EU should be taken seriously by the powers in East Asia as a possible player in maintaining the regional peace. I conclude that both global and regional security depend on continuing US unipolarity, strengthened by the co-operation of the EU in the form of multilateralism. By the same token, US unilateralism without a EU counter-balancing it, only invites potential challengers, such as China, to threaten the US’s preponderant position, thereby destabilising world peace.