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    题名: The Role of Catecholamines in Retention Performance of a Partially Baited Radial Eight-Arm Maze for Rats
    作者: Liao, Ruey-Ming;Lai, Wen-Sung;Lin, Jian-You;廖瑞銘
    关键词: dopamine;norepinephrine;place task;cue task;spatial memory;radial arm maze
    日期: 2002-12
    上传时间: 2010-09-02 10:58:47 (UTC+8)
    摘要: To assess the possible involvement of catecholaminergic neurotransmitters in maintenance of
    spatial cognition, the present work investigated the effects of dopaminergic and noradrenergic receptor
    antagonists on memory performance of rats in a partially baited radial eight-arm maze. Food-deprived
    rats were first trained to enter the arms baited with chocolate, and each subject was then randomly
    assigned to receive further training in either a place version or a cue version of the task. A specific
    pattern with four arms being baited was used throughout experimentation as the procedure for the place
    task; whereas four randomly chosen arms, each cued with a piece of sandpaper on the arm entrance, were
    baited from trial to trial as the procedure of the cue task. For drug evaluation, well-trained subjects were
    challenged with systemic injections of SCH23390, spiperone, haloperidol, prazosin, yohimbine, and
    propranolol. Regarding the place task, SCH23390, haloperidol, and propranolol, but not the other three
    drugs, significantly impaired behavioral performance by increasing the number of arm entries as well
    as the time to complete the task. The accuracy of performance as measured by the number of entries on
    the cue task was not significantly affected by any of these drugs tested. However, the times to complete
    the cue task were significantly increased with all drugs except yohimbine. These data show that blocking
    different catecholaminergic receptor subtypes produced distinct deficit patterns on the retention
    performance in a partially baited radial eight-arm maze. Evidently, both D1 and D2 dopamine receptors
    as well as β noradrenergic receptors are important in expression of spatial memory
    關聯: Chinese Journal of Physiology, 45(4), 177-185
    数据类型: article
    显示于类别:[心理學系] 期刊論文

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