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    Please use this identifier to cite or link to this item: http://nccur.lib.nccu.edu.tw/handle/140.119/61892

    Title: Quantitative Comparison of Post Processing Methods for Reduction of Frequency Modulation Sidebands in Non-water Suppression 1H MRS
    Authors: 蔡尚岳
    Lin, Jyh-Miin;Chuang, Tzu-Chao;Chung, Hsiao-Wen;Tsai, Shang-Yueh
    Contributors: 應物所
    Keywords: MRS and MRSI methods;other spectroscopic methods;artifacts and corrections;post-acquisition processing;non-water suppression;sidebands;frequency modulation;simultaneous diagonalization
    Date: 2012-12
    Issue Date: 2013-11-27 16:09:55 (UTC+8)
    Abstract: Non-water suppression MRS (NWS MRS) has several advantages. First, the unsuppressed water signal can be used as internal calibration for metabolite quantification and as a reliable frequency/phase reference for retrospective motion correction. Second, it avoids the potential artifacts caused by incomplete water suppression (WS) and extra radiofrequency deposition from WS pulses. However, the frequency modulation (FM) sidebands originating from a large water signal will distort the spectrum. Among the methods proposed to solve the problems caused by FM sidebands, post-acquisition processing methods are superior in flexibility for general use compared with experimental methods. In this study, we propose two algorithms based on advanced matrix decomposition to remove the FM sidebands. These methods, the simultaneous diagonalization (QZ) algorithm and its subsequent variant, the simultaneously generalized Schur decomposition (SGSD) algorithm, were numerically evaluated using computer simulations. In addition, we quantitatively compared the performance of these methods and the modulus method in an in vitro experiment and in vivo NWS MRS against conventional WS data. Our results show that the proposed SGSD algorithm can reduce the FM sidebands to achieve superior estimation of concentration on three major metabolites. This method can be applied directly to spectra pre-acquired under various experimental conditions without modifying the acquisition sequences.
    Relation: NMR in Biomedicine, 26(4),400-409
    Data Type: article
    DOI 連結: http://dx.doi.org/10.1002/nbm.2877
    DOI: 10.1002/nbm.2877
    Appears in Collections:[應用物理研究所 ] 期刊論文

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