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    政大機構典藏 > 商學院 > 統計學系 > 期刊論文 >  Item 140.119/62447
    Please use this identifier to cite or link to this item: http://nccur.lib.nccu.edu.tw/handle/140.119/62447

    Title: Two-stage analysis for gene-environment interaction utilizing both case-only and family-based analysis
    Authors: 程毅豪;林惠文;劉惠美
    Chen, Yi-Hau;Lin, Hui-Wen;Liu, Huimei
    Contributors: 政大統計系
    Keywords: case-parent studies;case-sibling studies;gene-environment independence;parental missingness
    Date: 2009-02
    Issue Date: 2013-12-12 18:09:16 (UTC+8)
    Abstract: The case-only study and family-based study are two popular study designs for detecting gene-environment interactions. It is well known that the case-only analysis is efficient, but its validity relies crucially on the assumption of gene-environment independence in the study population. In contrast, the family-based analysis is robust to the violation of such an assumption, but is less efficient. We propose a two-stage study design for detecting gene-environment interactions, where a case-only study is performed at the first stage, and a case-parent/case-sibling study is performed at the second stage on a random subsample of the first-stage case sample as well as their parents/unaffected siblings. Statistical inference procedures are developed for the proposed two-stage study designs, which not only preserve the robustness property of the family-based analysis, but also utilize information from the case-only analysis to enhance estimation efficiency and testing power. Simulation results reveal both the robustness and efficiency of the proposed strategies. Genet. Epidemiol. 2008. © 2008 Wiley-Liss, Inc.
    Relation: Genet Epidemiol, 33(2), 95-104
    Data Type: article
    DOI 連結: http://dx.doi.org/10.1002/gepi.20357
    DOI: 10.1002/gepi.20357
    Appears in Collections:[統計學系] 期刊論文

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