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    Title: Metabotropic glutamate receptor 5 modulates behavioral and hypothermic responses to toluene in rats
    Authors: Chan, Ming-Huan;Lee, Chia-Chi;Lin, Bih-Fen;Wu, Chia-Yen;Chen, Hwei-Hsien
    詹銘煥
    Contributors: 神科所
    Keywords: Toluene;mGluR5;NMDA receptor;Motor coordination;Learning;Hypothermia
    Date: 2012.12
    Issue Date: 2014-04-09 17:17:42 (UTC+8)
    Abstract: Toluene, a widely used and commonly abused organic solvent, produces various behavioral disturbances in both humans and animals. Blockade of N-methyl-d-aspartate (NMDA) receptors has been suggested to play a critical role in acute toluene-induced behavioral manifestations. Activation of type 5 metabotropic glutamate receptors (mGluR5) attenuates behavioral responses induced by NMDA receptor blockade. The present study elucidated the role of mGluR5 on toluene-induced behavioral and hypothermic responses. Male Sprague–Dawley rats received the mGluR5 agonist (RS)-2-chloro-5-hydroxyphenylglycine (CHPG) or antagonist 6-methyl-2-[phenylethynyl]-pyridine (MPEP) prior to toluene administration. Rotarod test, step-down inhibitory avoidance learning task, and rectal temperature were monitored. Pretreatment of CHPG and MPEP attenuated and potentiated these toluene-induced responses, respectively. In addition, the inhibitory effects of CHPG on toluene-induced motor incoordination, learning impairment, and hypothermia were reversed by the protein kinase C (PKC) inhibitor chelerythrine chloride. These findings suggest that mGluR5 may modulate the neural circuits responsible for motor incoordination, learning impairment, and hypothermic action of toluene through a PKC-dependent signal transduction pathway.
    Relation: Pharmacology, biochemistry and behavior,103(2), 418-424
    Source URI: http://dx.doi.org/10.1016/j.pbb.2012.09.019
    Data Type: article
    Appears in Collections:[Graduate Institute of Neuroscience] Periodical Articles

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