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    题名: Fast Mapping of T2 Relaxation Time of Cerebral Metabolites using Proton Echo-Planar Spectroscopic Imaging (PEPSI)
    作者: Tsai, Shang-Yueh;Posse, Stefan;Lin, Yi-Ru;Ko, Cheng-Wen;Otazo, Ricardo;Chung, Hsiao-Wen
    蔡尚岳
    贡献者: 應物所
    关键词: proton echo-planar spectroscopic imaging;single-voxel spectroscopy;T2 relaxation time;cerebral metabolites;gray/white matter difference
    日期: 2007.05
    上传时间: 2014-04-10 11:16:44 (UTC+8)
    摘要: Metabolite T2 is necessary for accurate quantification of the absolute concentration of metabolites using long-echo-time (TE) acquisition schemes. However, lengthy data acquisition times pose a major challenge to mapping metabolite T2. In this study we used proton echo-planar spectroscopic imaging (PEPSI) at 3T to obtain fast T2 maps of three major cerebral metabolites: N-acetyl-aspartate (NAA), creatine (Cre), and choline (Cho). We showed that PEPSI spectra matched T2 values obtained using single-voxel spectroscopy (SVS). Data acquisition for 2D metabolite maps with a voxel volume of 0.95 ml (32 × 32 image matrix) can be completed in 25 min using five TEs and eight averages. A sufficient spectral signal-to-noise ratio (SNR) for T2 estimation was validated by high Pearson's correlation coefficients between logarithmic MR signals and TEs (R2 = 0.98, 0.97, and 0.95 for NAA, Cre, and Cho, respectively). In agreement with previous studies, we found that the T2 values of NAA, but not Cre and Cho, were significantly different between gray matter (GM) and white matter (WM; P < 0.001). The difference between the T2 estimates of the PEPSI and SVS scans was less than 9%. Consistent spatial distributions of T2 were found in six healthy subjects, and disagreement among subjects was less than 10%. In summary, the PEPSI technique is a robust method to obtain fast mapping of metabolite T2. Magn Reson Med 57:859–865, 2007. © 2007 Wiley-Liss, Inc.
    關聯: Magnetic Resonance in Medicine ,57(5), 859-865
    数据类型: article
    DOI 連結: http://dx.doi.org/10.1002/mrm.21225
    DOI: 10.1002/mrm.21225
    显示于类别:[應用物理研究所 ] 期刊論文

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