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    Please use this identifier to cite or link to this item: http://nccur.lib.nccu.edu.tw/handle/140.119/65617


    Title: Comparison of Sagittal and Transverse Echo Planar Spectroscopic Imaging on the Quantification of Brain Metabolites
    Authors: 蔡尚岳
    Yeh, Chia-Jung;Tseng, Yu-Sheng;Lin, Yi-Ru;Tsai, Shang-Yueh;Huang, Teng-Yi
    Contributors: 應物所
    Keywords: Magnetic resonance spectroscopic imaging;brain metabolites;partial volume correction;echo planar spectroscopic imaging
    Date: 2013.12
    Issue Date: 2014-04-24 15:08:44 (UTC+8)
    Abstract: PURPOSE: We quantitatively compared sagittal and transverse echo planar spectroscopic imaging (EPSI) on the quantification of metabolite concentrations with consideration of tissue variation. A quantification strategy is proposed to collect the necessary information for quantification of concentrations in a minimized acquisition time. METHODS: Six transverse and six sagittal EPSI data were collected on healthy volunteers. Metabolite concentrations of N-acetyl-aspartate (NAA), total creatine (tCr), total choline (tCho), myo-inositol (mI), and glutamate and glutamine complex (Glx) were quantified using water scaling with partial volume and relaxation correction. Linear regression analysis was performed to extract concentrations in gray matter (GM) and white matter (WM). The inter- and intrasubject coefficients of variance (CV) were estimated. RESULTS: Concentrations and fitting errors of sagittal and transverse EPSI were at same level. GM to WM contrast of concentrations was found in NAA, tCr, and tCho. The intersubject CVs revealed greater variability in the sagittal EPSI than in the transverse EPSI. The intrasubject CVs of the transverse EPSI were below 5% for NAA, tCr, and tCho. CONCLUSION: We showed that quantified concentrations of sagittal and transverse EPSI after partial volume correction are comparable and reproducible. The proposed quantification strategy can be conveniently adapted into various MRI protocols.
    Relation: JOURNAL OF NEUROIMAGING, Article first published online: 5 MAR 2014
    Data Type: article
    DOI 連結: http://dx.doi.org/10.1111/jon.12087
    DOI: 10.1111/jon.12087
    Appears in Collections:[應用物理研究所 ] 期刊論文

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