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    题名: Comparison of Sagittal and Transverse Echo Planar Spectroscopic Imaging on the Quantification of Brain Metabolites
    作者: 蔡尚岳
    Yeh, Chia-Jung;Tseng, Yu-Sheng;Lin, Yi-Ru;Tsai, Shang-Yueh;Huang, Teng-Yi
    贡献者: 應物所
    关键词: Magnetic resonance spectroscopic imaging;brain metabolites;partial volume correction;echo planar spectroscopic imaging
    日期: 2013.12
    上传时间: 2014-04-24 15:08:44 (UTC+8)
    摘要: PURPOSE: We quantitatively compared sagittal and transverse echo planar spectroscopic imaging (EPSI) on the quantification of metabolite concentrations with consideration of tissue variation. A quantification strategy is proposed to collect the necessary information for quantification of concentrations in a minimized acquisition time. METHODS: Six transverse and six sagittal EPSI data were collected on healthy volunteers. Metabolite concentrations of N-acetyl-aspartate (NAA), total creatine (tCr), total choline (tCho), myo-inositol (mI), and glutamate and glutamine complex (Glx) were quantified using water scaling with partial volume and relaxation correction. Linear regression analysis was performed to extract concentrations in gray matter (GM) and white matter (WM). The inter- and intrasubject coefficients of variance (CV) were estimated. RESULTS: Concentrations and fitting errors of sagittal and transverse EPSI were at same level. GM to WM contrast of concentrations was found in NAA, tCr, and tCho. The intersubject CVs revealed greater variability in the sagittal EPSI than in the transverse EPSI. The intrasubject CVs of the transverse EPSI were below 5% for NAA, tCr, and tCho. CONCLUSION: We showed that quantified concentrations of sagittal and transverse EPSI after partial volume correction are comparable and reproducible. The proposed quantification strategy can be conveniently adapted into various MRI protocols.
    關聯: JOURNAL OF NEUROIMAGING, Article first published online: 5 MAR 2014
    数据类型: article
    DOI 連結: http://dx.doi.org/10.1111/jon.12087
    DOI: 10.1111/jon.12087
    显示于类别:[應用物理研究所 ] 期刊論文

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