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    Please use this identifier to cite or link to this item: http://nccur.lib.nccu.edu.tw/handle/140.119/65800

    Title: Temporal correlation-based dynamic contrast-enhanced MR imaging improves assessment of complex pulmonary circulation in congenital heart disease
    Authors: 蔡尚岳
    Contributors: 應物所
    Keywords: congenital heart disease;contrast-enhanced MRI;cross-correlation analysis;pulmonary circulation;temporal correlation map
    Date: 2006.08
    Issue Date: 2014-05-01 17:47:06 (UTC+8)
    Abstract: A temporal correlation (TC) mapping method is proposed to help bolus chasing during dynamic contrast-enhanced (DCE) MRI of complex pulmonary circulation (CPC) in patients with congenital heart disease. DCE-MRI was performed on five healthy male subjects (23–24 years old) and 25 patients (nine males and 16 females, 0.25–44 years old), and TC maps were generated by performing pixel-based computation of cross-correlations to the pulmonary artery with a series of time shifts in all subjects. Qualitative and quantitative evaluations were performed in comparison with original DCE images. TC maps exhibited a better signal-to-noise ratio (SNR) by factors of 4.3 and 1.3 in the lung parenchyma, pulmonary veins, and superior artery/vein; a better intraparenchymal contrast-to-noise ratio (CNR) by factors of 1.5–5.4; and a significantly higher conspicuity in all regions except the pulmonary arteries when graded with a five-point score. TC maps evaluated by two experienced clinicians significantly added relevant information (P < 0.001), and in some cases affected the final diagnosis. We conclude that TC maps facilitate bolus chasing for DCE-MRI by reducing recirculation effects and interframe fluctuations, and hence complements morphological imaging of CPC in patients with complex congenital heart disease. Magn Reson Med, 2006. © 2006 Wiley-Liss, Inc.
    Relation: Magn Reson Med, 56(3), 517-526
    Data Type: article
    Appears in Collections:[應用物理研究所 ] 期刊論文

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