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    Please use this identifier to cite or link to this item: http://nccur.lib.nccu.edu.tw/handle/140.119/70162


    Title: Concurrent sympathetic activation and vagal withdrawal in hyperthyroidism: evidence from detrended fluctuation analysis of heart rate variability
    Authors: 蕭又新
    Jin-Long Chen;Yuo-Hsien Shiau;Yin-Jiun Tseng;Hung-Wen Chiu;Tzu-Chien Hsiao;Niels Wessel;Jürgen Kurths;Woei-Chyn Chu
    Contributors: 應物所
    Keywords: Hyperthyroidism;Autonomic nervous system;Heart rate variability;Detrended fluctuation analysis;Nonlinear dynamics
    Date: 2010.05
    Issue Date: 2014-09-25 12:22:46 (UTC+8)
    Abstract: Despite many previous studies on the association between hyperthyroidism and the hyperadrenergic state, controversies still exist. Detrended fluctuation analysis (DFA) is a well recognized method in the nonlinear analysis of heart rate variability (HRV), and it has physiological significance related to the autonomic nervous system. In particular, an increased short-term scaling exponent α1 calculated from DFA is associated with both increased sympathetic activity and decreased vagal activity. No study has investigated the DFA of HRV in hyperthyroidism. This study was designed to assess the sympathovagal balance in hyperthyroidism. We performed the DFA along with the linear analysis of HRV in 36 hyperthyroid Graves’ disease patients (32 females and 4 males; age 30 ± 1 years, means ± SE) and 36 normal controls matched by sex, age and body mass index. Compared with the normal controls, the hyperthyroid patients revealed a significant increase (P<0.001) in α1 (hyperthyroid 1.28±0.04 versus control 0.91±0.02), long-term scaling exponent View the MathML source, overall scaling exponent View the MathML source, low frequency power in normalized units (LF%) and the ratio of low frequency power to high frequency power (LF/HF); and a significant decrease (P<0.001) in the standard deviation of the R–R intervals (SDNN) and high frequency power (HF). In conclusion, hyperthyroidism is characterized by concurrent sympathetic activation and vagal withdrawal. This sympathovagal imbalance state in hyperthyroidism helps to explain the higher prevalence of atrial fibrillation and exercise intolerance among hyperthyroid patients.
    Relation: Physica A: Statistical Mechanics and its Applications,389(9),1861-1868
    Data Type: article
    DOI 連結: http://dx.doi.org/10.1016/j.physa.2009.12.062
    DOI: 10.1016/j.physa.2009.12.062
    Appears in Collections:[應用物理研究所 ] 期刊論文

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