政大機構典藏-National Chengchi University Institutional Repository(NCCUR):Item 140.119/71636
English  |  正體中文  |  简体中文  |  Post-Print筆數 : 27 |  全文笔数/总笔数 : 109952/140891 (78%)
造访人次 : 46259213      在线人数 : 1079
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻


    请使用永久网址来引用或连结此文件: https://nccur.lib.nccu.edu.tw/handle/140.119/71636


    题名: Statistical Mapping of Metabolites in The Medial Wall of The Brain: A Proton Echo Planar Spectroscopic Imaging Study
    作者: 蔡尚岳
    Niddam, David M.;Tsai, Shang-Yueh;Lin, Yi-Ru
    贡献者: 應物所
    关键词: normal aging;cingulate cortex;magnetic resonance spectroscopic imaging;statistical nonparametric mapping;creatine
    日期: 2014-10
    上传时间: 2014-11-24 15:18:06 (UTC+8)
    摘要: With magnetic resonance spectroscopic imaging (MRSI), it is possible to simultaneously map distributions of several brain metabolites with relatively good spatial resolution in a short time. Although other functional imaging modalities have taken advantage of population-based inferences using spatially extended statistics, this approach remains little utilized for MRSI. In this study, statistical nonparametric mapping (SnPM) was applied to two-dimensional MRSI data from the medial walls of the human brain to assess the effect of normal aging on metabolite concentrations. The effects of different preprocessing steps on these results were then explored. Short echo time MRSI of left and right medial walls was acquired in conjunction with absolute quantification of total choline, total creatine (tCr), glutamate and glutamine, myo-inositol, and N-acetyl-aspartate. Individual images were spatially warped to a common anatomical frame of reference. Age effects were assessed within SnPM as were the effects of voxel subsampling, variance smoothing, and spatial smoothing. The main findings were: (1) regions in the bilateral dorsal anterior cingulate and in the left posterior cingulate exhibited higher tCr concentrations with age; (2) voxel subsampling but not spatial smoothing enhanced the cluster-level statistical sensitivity; and (3) variance smoothing was of little benefit in this study. Our study shows that spatially extended statistics can yield information about regional-specific changes in metabolite concentrations obtained by short echo time MRSI. This opens up the possibility for systematic comparisons of metabolites in the medial wall of the brain.
    關聯: Human Brain Mapping,
    数据类型: article
    DOI 連結: http://dx.doi.org/10.1002/hbm.22669
    DOI: 10.1002/hbm.22669
    显示于类别:[應用物理研究所 ] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    StatisticalMapping.pdf329KbAdobe PDF2951检视/开启


    在政大典藏中所有的数据项都受到原著作权保护.


    社群 sharing

    著作權政策宣告 Copyright Announcement
    1.本網站之數位內容為國立政治大學所收錄之機構典藏，無償提供學術研究與公眾教育等公益性使用，惟仍請適度，合理使用本網站之內容，以尊重著作權人之權益。商業上之利用，則請先取得著作權人之授權。
    The digital content of this website is part of National Chengchi University Institutional Repository. It provides free access to academic research and public education for non-commercial use. Please utilize it in a proper and reasonable manner and respect the rights of copyright owners. For commercial use, please obtain authorization from the copyright owner in advance.

    2.本網站之製作，已盡力防止侵害著作權人之權益，如仍發現本網站之數位內容有侵害著作權人權益情事者，請權利人通知本網站維護人員(nccur@nccu.edu.tw)，維護人員將立即採取移除該數位著作等補救措施。
    NCCU Institutional Repository is made to protect the interests of copyright owners. If you believe that any material on the website infringes copyright, please contact our staff(nccur@nccu.edu.tw). We will remove the work from the repository and investigate your claim.
    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈