English  |  正體中文  |  简体中文  |  Post-Print筆數 : 11 |  Items with full text/Total items : 88987/118697 (75%)
Visitors : 23573312      Online Users : 170
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    政大機構典藏 > 理學院 > 心理學系 > 期刊論文 >  Item 140.119/75238
    Please use this identifier to cite or link to this item: http://nccur.lib.nccu.edu.tw/handle/140.119/75238


    Title: Oxidative stress status in recently abstinent methamphetamine abusers
    Authors: Huang, M.-C.;Lin, S.-K.;Chen, Chen C.-H.;Pan, Chun-Hung;Lee, C.-H.;Liu, H.-C.
    潘俊宏
    Contributors: 心理系
    Keywords: catalase;glutathione;malonaldehyde;methamphetamine;superoxide dismutase;adult;article;comparative study;controlled study;drug abuse;drug withdrawal;enzyme blood level;female;human;major clinical study;male;oxidative stress;smoking;urinalysis;Adult;Amphetamine-Related Disorders;Antioxidants;Case-Control Studies;Catalase;Female;Glutathione;Humans;Male;Malondialdehyde;Methamphetamine;Oxidative Stress;Superoxide Dismutase
    Date: 2013-02
    Issue Date: 2015-05-21 16:33:31 (UTC+8)
    Abstract: Aim Methamphetamine (METH) administration is associated with excessive oxidative stress. It is not known whether the systemic oxidative stress indices would alter during early abstinence in METH abusers with positive urine testing for recent METH exposure. Methods Sixty-four non-treatment-seeking METH abusers enrolled from a controlled environment and 60 healthy controls participated in the study. Fasting serum malondialdehyde (MDA) levels and anti-oxidant indices, including superoxide dismutase (SOD) and catalase (CAT) activity, and glutathione (GSH) levels, were measured at baseline and 2 weeks after the first measurement. We compared the differences of these oxidative stress indices between METH abusers and controls and examined the changes of the indices 2 weeks after baseline in the METH group. Results At baseline, the recently abstinent METH abusers had significantly higher MDA levels, lower SOD activity, and higher CAT activity and GSH levels compared to healthy controls. CAT and GSH values were positively correlated with MDA but negatively correlated with SOD. These oxidative stress indices did not significantly correlate with age, smoking amount, Alcohol Use Disorder Identification Test scores, or METH use variables. After 2 more weeks of abstinence, the indices did not alter nor normalize. Conclusion Compared to controls, we found that METH abusers have persistently higher systemic oxidative stress throughout early abstinence. The compromised SOD as well as elevated CAT activity and GSH levels may act together as a compensatory mechanism to counteract excessive oxidative stress induced by METH. Whether the oxidative stress could improve after a longer period of abstinence needs to be examined in future studies. © 2013 The Authors. Psychiatry and Clinical Neurosciences © 2013 Japanese Society of Psychiatry and Neurology.
    Relation: Psychiatry and Clinical Neurosciences, 67(2), 92-100
    Data Type: article
    DOI 連結: http://dx.doi.org/10.1111/pcn.12025
    DOI: 10.1111/pcn.12025
    Appears in Collections:[心理學系] 期刊論文

    Files in This Item:

    File Description SizeFormat
    92-100.pdf83KbAdobe PDF628View/Open


    All items in 政大典藏 are protected by copyright, with all rights reserved.


    社群 sharing

    著作權政策宣告
    1.本網站之數位內容為國立政治大學所收錄之機構典藏,無償提供學術研究與公眾教育等公益性使用,惟仍請適度,合理使用本網站之內容,以尊重著作權人之權益。商業上之利用,則請先取得著作權人之授權。
    2.本網站之製作,已盡力防止侵害著作權人之權益,如仍發現本網站之數位內容有侵害著作權人權益情事者,請權利人通知本網站維護人員(nccur@nccu.edu.tw),維護人員將立即採取移除該數位著作等補救措施。
    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback