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    政大機構典藏 > 商學院 > 統計學系 > 會議論文 >  Item 140.119/75321
    Please use this identifier to cite or link to this item: http://nccur.lib.nccu.edu.tw/handle/140.119/75321


    Title: Biomarker Selection in Medical Diagnosis
    Authors: Hsu, Man-Jen;Chang, Yuan-Chin Ivan;Hsueh, Huey-Miin
    許嫚荏;張源俊;薛慧敏
    Contributors: 統計系
    Keywords: Biomarker selections;Confirmatory analysis;Discriminatory power;Receiver operating characteristic curves;Sensitivity and specificity;Statistical evidence;Statistical significance;Statistical testing;Diagnosis;Optimization;Biomarkers
    Date: 2013-06
    Issue Date: 2015-05-26 18:16:58 (UTC+8)
    Abstract: A biomarker is usually used as a diagnostic or assessment tool in medical research. Finding a single ideal biomarker of a high level of both sensitivity and specificity is not an easy task; especially when a high specificity is required for a population screening tool. Combining multiple biomarkers is a promising alternative and can provide a better overall performance than the use of a single biomarker. It is known that the area under the receiver operating characteristic (ROC) curve is most popular for evaluation of a diagnostic tool. In this study, we consider the criterion of the partial area under the ROC curve (pAUC) for the purpose of population screening. Under the binormality assumption, we obtain the optimal linear combination of biomarkers in the sense of maximizing the pAUC with a pre-specified specificity level. Furthermore, statistical testing procedures based on the optimal linear combination are developed to assess the discriminatory power of a biomarker set and an individual biomarker, respectively. Stepwise biomarker selections, by embedding the proposed tests, are introduced to identify those biomarkers of statistical significance among a biomarker set. Rather than for an exploratory study, our methods, providing computationally intensive statistical evidence, are more appropriate for a confirmatory analysis, where the data has been adequately filtered. The applicability of the proposed methods are shown via several real data sets with a moderate number of biomarkers. © Springer Science+Business Media New York 2013.
    Relation: Springer Proceedings in Mathematics and Statistics, 55, 2013, 111-121, 21st Symposium of the International Chinese Statistical Association, ICSA 2012; Boston, MA; United States; 23 June 2012 到 26 June 2012; 代碼 100347
    Data Type: conference
    DOI 連結: http://dx.doi.org/10.1007/978-1-4614-7846-1_10
    DOI: 10.1007/978-1-4614-7846-1_10
    Appears in Collections:[統計學系] 會議論文

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