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    題名: BMP4 Is a Peripherally-Derived Factor for Motor Neurons and Attenuates Glutamate-Induced Excitotoxicity In Vitro
    作者: Chou, Hui-Ju;Lai, D.-M.;Huang, C.-W.;McLennan, I.S.;Wang, H.-D.;Wang, Pei-Yu
    周慧茹
    貢獻者: 神科所
    關鍵詞: bone morphogenetic protein 4;bone morphogenetic protein receptor 2;glutamic acid;messenger RNA;animal cell;article;cell interaction;cell protection;cell survival;controlled study;down regulation;immunoreactivity;in vitro study;motoneuron;mouse;muscle cell;nerve cell necrosis;nerve fiber;nerve ligation;neuromuscular synapse;nonhuman;protein analysis;protein expression;protein transport;Schwann cell;skeletal muscle;upregulation
    日期: 2013-03
    上傳時間: 2015-05-28 17:39:07 (UTC+8)
    摘要: Bone morphogenetic proteins (BMPs), members of the transforming growth factor-beta (TGF-β) superfamily, have been shown to play important roles in the nervous system, including neuronal survival and synaptogenesis. However, the physiological functions of BMP signaling in the mammalian neuromuscular system are not well understood. In this study, we found that proteins of the type II bone morphogenetic receptors (BMPRII) were detected at the neuromuscular junction (NMJ), and one of its ligands, BMP4, was expressed by Schwann cells and skeletal muscle fibers. In double-ligated nerves, BMP4 proteins accumulated at the proximal and distal portions of the axons, suggesting that Schwann cell- and muscle fiber-derived BMP4 proteins were anterogradely and retrogradely transported by motor neurons. Furthermore, BMP4 mRNA was down-regulated in nerves but up-regulated in skeletal muscles following nerve ligation. The motor neuron-muscle interactions were also demonstrated using differentiated C2C12 muscle cells and NG108-15 neurons in vitro. BMP4 mRNA and immunoreactivity were significantly up-regulated in differentiated C2C12 muscle cells when the motor neuron-derived factor, agrin, was present in the culture. Peripherally-derived BMP4, on the other hand, promotes embryonic motor neuron survival and protects NG108-15 neurons from glutamate-induced excitotoxicity. Together, these data suggest that BMP4 is a peripherally-derived factor that may regulate the survival of motor neurons. © 2013 Chou et al.
    關聯: PLoS ONE, 8(3), 論文編號 e58441
    資料類型: article
    DOI: http://dx.doi.org/10.1371/journal.pone.0058441
    顯示於類別:[神經科學研究所 ] 期刊論文

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