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    政大機構典藏 > 理學院 > 心理學系 > 期刊論文 >  Item 140.119/77938
    Please use this identifier to cite or link to this item: http://nccur.lib.nccu.edu.tw/handle/140.119/77938

    Title: Glutamate theory in developing novel pharmacotherapies for obsessive compulsive disorder: Focusing on N-methyl-D-aspartate signaling
    Authors: Tang, Hwa-Sheng
    Wu, Po-Lun
    Lane, Hsien-Yuan
    Tsai, Guochuan E.
    Contributors: 心理系
    Keywords: glutamate;N-methyl-D-aspartate;obsessive compulsive disorder
    Date: 2012-06
    Issue Date: 2015-08-24 10:55:19 (UTC+8)
    Abstract: Obsessive compulsive disorder (OCD) is a prevalent and debilitating illness that often follows a chronic course. Up to 40% of OCD patients received little or no benefit from currently available pharmacotherapy or exposure-based behavior psychotherapy. Thus, there is an urgent need to develop new strategies for the treatment of OCD. Although the neurobiology and etiology of OCD are not completely understood, growing clinical and preclinical evidence appears to support the abnormalities of glutamatergic neurotransmission, including N-methyl-D-aspartate subtype receptor (NMDAR) function, in the pathophysiology and treatment of OCD. This review summarizes the findings from neuro imaging, candidate genes, animal models, and treatment studies in the context of glutamatergic dysregulation, with particular emphasis on the synaptic NMDAR function. The converging evidence indicates the potential of glutamate-modulating agents in the development of novel treatment for OCD.
    Relation: BioMedicine, 2(2), 75-79
    Data Type: article
    DOI 連結: http://dx.doi.org/10.1016/j.biomed.2012.04.003
    DOI: 10.1016/j.biomed.2012.04.003
    Appears in Collections:[心理學系] 期刊論文

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