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    政大機構典藏 > 商學院 > 統計學系 > 期刊論文 >  Item 140.119/79348
    Please use this identifier to cite or link to this item: http://nccur.lib.nccu.edu.tw/handle/140.119/79348


    Title: Simple association analysis combining data from trios/sibships and unrelated controls
    Authors: Lin, Hui-Wen
    林惠文
    Contributors: 統計學系
    Keywords: case-control studies;combined association analysis;family-based association analysis;population-based association analysis
    Date: 2008-03
    Issue Date: 2015-11-05 18:28:30 (UTC+8)
    Abstract: We consider genetic association analysis that combines data from case-parent trios/sibships and unrelated controls. A general and simple methodology is proposed, using a weighted least-squares approach to combine separate information from the case-parent/case-sibling analysis and the case-unrelated control analysis. The new proposal improves over the existing methods in that it requires no assumptions and estimation on the mating-type distribution. Simulation results show that the new method competes well with the likelihood-based method when the latter is applicable, and achieves substantial power gains over separate analyses in general. Therefore, the proposed combined association analysis can enjoy wide applications, including the multiallele/locus, haplotype, and genome-wide association studies
    Relation: Genetic Epidemiology,32(6),520-527
    Data Type: article
    DOI 連結: http://dx.doi.org/10.1002/gepi.20325
    DOI: 10.1002/gepi.20325
    Appears in Collections:[統計學系] 期刊論文

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