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    题名: MeCP2 in the rostral striatum maintains local dopamine content critical for psychomotor control
    作者: Su, San-Hua;Kao, Fang-Chi;Huang, Yi-Bo;Liao, Wenlin
    廖文霖
    贡献者: 神科所
    关键词: dopamine;methyl-CpG binding protein 2;motor control;Rett syndrome;striatum
    日期: 2015-04
    上传时间: 2016-01-14 11:39:34 (UTC+8)
    摘要: Methyl-CpG binding protein 2 (MeCP2) is a chromatin regulator highly expressed in mature neurons. Mutations of MECP2 gene cause >90% cases of Rett syndrome, a neurodevelopmental disorder featured by striking psychomotor dysfunction. In Mecp2-null mice, the motor deficits are associated with reduction of dopamine content in the striatum, the input nucleus of basal ganglia mostly composed of GABAergic neurons. Here we investigated the causal role of MeCP2 in modulation of striatal dopamine content and psychomotor function. We found that mice with selective removal of MeCP2 in forebrain GABAergic neurons, predominantly in the striatum, phenocopied Mecp2-null mice in dopamine deregulation and motor dysfunction. Selective expression of MeCP2 in the striatum preserved dopamine content and psychomotor function in both males and females. Notably, the dopamine deregulation was primarily confined to the rostral striatum, and focal deletion or reactivation of MeCP2 expression in the rostral striatum through adeno-associated virus effectively disrupted or restored dopamine content and locomotor activity, respectively. Together, these findings demonstrate that striatal MeCP2 maintains local dopamine content in a non-cell autonomous manner in the rostral striatum and that is critical for psychomotor control.
    關聯: The Journal of Neuroscience, 35, 15, 6209-6220.
    数据类型: article
    DOI 連結: http://dx.doi.org/10.1523/JNEUROSCI.4624-14.2015
    DOI: 10.1523/JNEUROSCI.4624-14.2015
    显示于类别:[神經科學研究所 ] 期刊論文

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    7._Su,_MeCP2_in_ST-r_(JN,_2015).pdf4142KbAdobe PDF108检视/开启


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