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    題名: Three arginine-rich cell-penetrating peptides facilitate cellular internalization of red-emitting quantum dots
    作者: Liu, B.R.;Chen, H.H.;Chan, M.H.;Huang, Y.W.;Aronstam, R.S;Lee, H.J.*
    貢獻者: 神科所
    日期: 2015
    上傳時間: 2016-01-14 17:57:16 (UTC+8)
    摘要: Nanoparticles, such as semiconductor quantum dots (QDs), have been found increasing use in biomedical diagnosis and therapeutics because of their unique properties, including quantum confinement, surface plasmon resonance, and superparamagnetism. Cell-penetrating peptides (CPPs) represent an efficient mechanism to overcome plasma membrane barriers and deliver biologically active molecules into cells. In this study, we demonstrate that three arginine-rich CPPs (SR9, HR9, and PR9) can noncovalently complex with red light emitting QDs, dramatically increasing their delivery into living cells. Zeta-potential and size analyses highlight the importance of electrostatic interactions between positive-charged CPP/QD complexes and negative-charged plasma membranes indicating the efficiency of transmembrane complex transport. Subcellular colocalization indicates associations of QD with early endosomes and lysosomes following PR9-mediated delivery. Our study demonstrates that nontoxic CPPs of varied composition provide an effective vehicle for the design of optimized drug delivery systems.
    關聯: Journal of Nanoscience and Nanotechnology, 15, 2067-2078.
    資料類型: article
    DOI 連結: http://dx.doi.org/10.1166/jnn.2015.9148
    DOI: 10.1166/jnn.2015.9148
    顯示於類別:[應用物理研究所 ] 期刊論文

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