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    Please use this identifier to cite or link to this item: http://nccur.lib.nccu.edu.tw/handle/140.119/111257

    Title: 1H MR spectroscopy in cervical carcinoma using external phase array body coil at 3.0 Tesla: Prediction of poor prognostic human papillomavirus genotypes
    Authors: Lin, Gigin;Ng, Koon‐Kwan;Ng, Shu‐Hang
    Lai, Chyong‐Huey
    Tsai, Shang‐Yueh
    Lin, Yu‐Chun
    Huang, Yu‐Ting
    Wu, Ren‐Chin
    Yang, Lan‐Yan
    Lu, Hsin‐Ying
    Chao, Angel
    Wang, Chiun‐Chieh
    Hung, Ji‐Hong
    Yen, Tzu‐Chen
    Chou, Hung‐Hsueh
    Contributors: 應物所
    Date: 2017
    Issue Date: 2017-07-19 16:26:20 (UTC+8)
    Abstract: Purpose: To assess the clinical value of proton (1H) MR spectroscopy in cervical carcinomas, in the prediction of poor prognostic human papillomavirus (HPV) genotypes as well as persistent disease following concurrent chemoradiotherapy (CCRT). Materials and Methods: 1H MR spectroscopy using external phase array coil was performed in 52 consecutive cervical cancer patients at 3 Tesla (T). Poor prognostic HPV genotypes (alpha-7 species or absence of HPV infection) and persistent cervical carcinoma after CCRT were recorded. Statistical significance was calculated with the Mann-Whitney two-sided nonparametric test and areas under the receiver operating characteristics curve (AUC) analysis. Results: A 4.3-fold (P = 0.032) increased level of methyl resonance at 0.9 ppm was found in the poor prognostic HPV genotypes, mainly attributed to the presence of HPV18, with a sensitivity of 75%, a specificity of 81%, and an AUC of 0.76. Poor prognostic HPV genotypes were more frequently observed in patients with adeno-/adenosquamous carcinoma (Chi-square, P < 0.0001). In prediction of the four patients with persistent disease after CCRT, elevated methyl resonance demonstrated a sensitivity of 100%, a specificity of 74%, and an AUC of 0.82. Conclusion: 1H MR spectroscopy at 3T can be used to depict the elevated lipid resonance levels in cervical carcinomas, as well as help to predict the poor prognostic HPV genotypes and persistent disease following CCRT. Further large studies with longer follow up times are warranted to validate our initial findings. Level of Evidence: 1. J. Magn. Reson. Imaging 2017;45:899–907. © 2016 International Society for Magnetic Resonance in Medicine
    Relation: Journal of Magnetic Resonance Imaging, 45(3), 899-907
    Data Type: article
    DOI 連結: http://dx.doi.org/10.1002/jmri.25386
    DOI: 10.1002/jmri.25386
    Appears in Collections:[應用物理研究所 ] 期刊論文

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