政大機構典藏-National Chengchi University Institutional Repository(NCCUR):Item 140.119/112529

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题名:	Evaluating the impact of hippocampal sparing during whole brain radiotherapy on neurocognitive functions: A preliminary report of a prospective phase II study.
作者:	楊啟正 Lin, Shinn‑Yn Yang, Chi‑Cheng Wu, Yi‑Ming Tseng, Chen‑Kan Wei, Kuo‑Chen Chu, Yi‑Chuan Hsieh, Hsiang‑Yao Wu1, Tung‑Ho Pai, Ping‑Ching Hsu, Peng‑Wei
贡献者:	心理系
日期:	2015-09
上传时间:	2017-09-06 16:29:07 (UTC+8)
摘要:	BACKGROUND: Whole brain radiotherapy (WBRT) is the treatment of choice for patients with brain metastases. However, neurocognitive functions (NCFs) decline due to impaired hippocampal neurogenesis might occur thereafter. It is hypothesized that conformal hippocampal avoidance during the course of WBRT (HA-WBRT) might provide meaningful NCF preservation. Our study aims to demonstrate the impact of delivering HA-WBRT on NCF changes in patients receiving WBRT. METHODS: Twenty-five patients who were referred for prophylactic cranial irradiation (PCI) or treating oligometastatic brain disease were enrolled in the study. Before the HA-WBRT course, all participants should receive baseline neurocognitive assessment, including memory, executive functions, and psychomotor speed. The primary endpoint was delayed recall, as determined by the change/decline in verbal memory [Wechsler Memory Scale - 3rd edition (WMS III)- Word List score] from the baseline assessment to 4 months after the start of HA-WBRT.
關聯:	Biomedical Journal, Vol.38, No.5, pp.439-449
数据类型:	article
DOI 連結:	https://doi.org/10.4103/2319-4170.157440
DOI:	10.4103/2319-4170.157440
显示于类别:	[心理學系] 期刊論文

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