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Please use this identifier to cite or link to this item: https://nccur.lib.nccu.edu.tw/handle/140.119/114852

Title:	Natural history of acute and chronic hepatitis B: The role of HBV genotypes and mutants
Authors:	林志陵 Lin, Chih-Lin Kao, Jia-Horng
Contributors:	心理系
Keywords:	Chronic hepatitis B;Hepatitis B virus (HBV);Genotype;HBV mutant;Cirrhosis;Hepatocellular carcinoma
Date:	2017-06
Issue Date:	2017-11-22 15:45:57 (UTC+8)
Abstract:	Molecular epidemiologic studies reveal remarkable differences in the geographical distribution of hepatitis B virus (HBV) genotypes. The frequency of mutants among HBV genotypes also varies. The role of HBV genotypes/mutants in the pathogenesis of HBV infection and natural history of HBV infection has been extensively investigated. The distribution of HBV genotypes in acute hepatitis B patients reflects the predominant genotypes in a given geographic area. In chronic hepatitis B patients, genotype C and D have a higher frequency of basal core promoter A1762T/G1764A mutations than genotype A and B. HBV genotypes C, D and F carry a higher lifetime risk of cirrhosis and HCC development than genotype A and B. HBV pre-S/S gene mutations were associated with immune escape of hepatitis B immunoglobulin or vaccine-induced immunity. Mutations in the pre-S, core promoter and X regions correlate with an increased risk of cirrhosis and HCC. In summary, HBV genotypes and mutants are associated with the disease progression and long-term outcome of HBV infection. They may serve as viral genetic markers for risk stratification of chronic hepatitis B patients in clinical practice.
Relation:	Best Practice & Research Clinical Gastroenterology, Volume 31, Issue 3, Pages 249-255
Data Type:	article
DOI 連結:	https://doi.org/10.1016/j.bpg.2017.04.010
DOI:	10.1016/j.bpg.2017.04.010
Appears in Collections:	[心理學系] 期刊論文

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