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政大機構典藏 > 研究中心 > 心智‧大腦與學習研究中心 > 期刊論文 > Item 140.119/120071

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题名:	Strong Circadian Rhythms in the Choroid Plexus: Implications for Sleep-Independent Brain Metabolite Clearance
作者:	Myung, Jihwan;Wu, Dean;Simonneaux, Valérie;Lane, Timothy Joseph 藍亭 Lane, Timothy Joseph
贡献者:	心腦中心
关键词:	Choroid plexus;circadian clock;metabolite clearance;neurodegenerative disease
日期:	2018
上传时间:	2018-09-11 18:34:10 (UTC+8)
摘要:	Cerebrospinal fluid (CSF) is a fluidic part of the brain’s microenvironment that isolates the brain from the rest of the body. CSF dilutes metabolites from neuronal activities and removes them from the brain. Its production and resorption are regulated dynamically and are central to maintaining brain homeostasis. We discovered that the major CSF source, the choroid plexus (CP), harbors the brain’s strongest circadian clock. Here, we consider some implications of the CP circadian clock for metabolite clearance in the brain. If the circadian clock contributes to timed production of the CSF, its synchronization with sleep timing can maximize clearance efficiency and help prevent neurodegenerative diseases such as Alzheimer’s disease.
關聯:	Journal of Experimental Neuroscience, Vol.12
数据类型:	article
DOI 連結:	https://doi.org/10.1177/1179069518783762
DOI:	10.1177/1179069518783762
显示于类别:	[心智‧大腦與學習研究中心 ] 期刊論文

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