 |
English
|
正體中文
|
简体中文
|
Post-Print筆數 : 27 |
Items with full text/Total items : 109948/140897 (78%)
Visitors : 46109761
Online Users : 1137
|
|
|
Loading...
|
Please use this identifier to cite or link to this item:
https://nccur.lib.nccu.edu.tw/handle/140.119/120082
|
| Title: | Vascular-metabolic and GABAergic Inhibitory Correlates of Neural Variability Modulation. A Combined fMRI and PET Study |
| Authors: | Qin, Pengmin;Duncan, Niall W.;Chen, David Yen-Ting;Chen, Chi-Jen;Huang, Li-Kai;Huang, Zirui;Lin, Chien-Yuan E.;Wiebking, Christine;Yang, Che-Ming;Northoff, Georg;Lane, Timothy J.
Northoff, Georg
藍亭
Lane, Timothy J. |
| Contributors: | 心腦中心 |
| Keywords: | temporal variability;brain state;cerebral blood flow;visual cortex;GABAA receptor;flumazenil |
| Date: | 2018-05 |
| Issue Date: | 2018-09-13 17:43:12 (UTC+8) |
| Abstract: | Neural activity varies continually from moment to moment. Such temporal variability (TV) has been highlighted as a functionally specific brain property playing a fundamental role in cognition. We sought to investigate the mechanisms involved in TV changes between two basic behavioral states, namely having the eyes open (EO) or eyes closed (EC) in vivo in humans. To these ends we acquired BOLD fMRI, ASL, and [18F]-fluoro-deoxyglucose PET in a group of healthy participants (n = 15), along with BOLD fMRI and [18F]-flumazenil PET in a separate group (n = 19). Focusing on an EO- vs EC-sensitive region in the occipital cortex (identified in an independent sample), we show that TV is constrained in the EO condition compared to EC. This reduction is correlated with an increase in energy consumption and with regional GABAA receptor density. This suggests that the modulation of TV by behavioral state involves an increase in overall neural activity that is related to an increased effect from GABAergic inhibition in addition to any excitatory changes. These findings contribute to our understanding of the mechanisms underlying activity variability in the human brain and its control. |
| Relation: | Neuroscience, Volume 379, 21 May 2018, Pages 142-151 |
| Data Type: | article |
| DOI 連結: | https://doi.org/10.1016/j.neuroscience.2018.02.041 |
| DOI: | 10.1016/j.neuroscience.2018.02.041 |
| Appears in Collections: | [心智‧大腦與學習研究中心 ] 期刊論文
|
Files in This Item:
| File |
Description |
Size | Format | |
|---|
| 142151.pdf | | 798Kb | Adobe PDF2 | 390 | View/Open |
|
All items in 政大典藏 are protected by copyright, with all rights reserved.
|
著作權政策宣告 Copyright Announcement1.本網站之數位內容為國立政治大學所收錄之機構典藏，無償提供學術研究與公眾教育等公益性使用，惟仍請適度，合理使用本網站之內容，以尊重著作權人之權益。商業上之利用，則請先取得著作權人之授權。
The digital content of this website is part of National Chengchi University Institutional Repository. It provides free access to academic research and public education for non-commercial use. Please utilize it in a proper and reasonable manner and respect the rights of copyright owners. For commercial use, please obtain authorization from the copyright owner in advance.
2.本網站之製作，已盡力防止侵害著作權人之權益，如仍發現本網站之數位內容有侵害著作權人權益情事者，請權利人通知本網站維護人員(
nccur@nccu.edu.tw)，維護人員將立即採取移除該數位著作等補救措施。
NCCU Institutional Repository is made to protect the interests of copyright owners. If you believe that any material on the website infringes copyright, please contact our staff(
nccur@nccu.edu.tw). We will remove the work from the repository and investigate your claim.
