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Please use this identifier to cite or link to this item:
https://nccur.lib.nccu.edu.tw/handle/140.119/141506
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| Title: | Neuropsychological performances in patients with infiltrative non-GBM gliomas after postoperative adjuvant photon or proton radiotherapy: A prospective and preliminary investigation |
| Authors: | 楊啟正
Yang, Chi-Cheng
Lin, Shinn-Yn;Chuang, Chi-Cheng;Huang, Yin-Cheng;Pai, Ping-Ching;Lee, Cheng-Chi;Wei, Kuo-Chen;Tseng, Chen-Kan |
| Contributors: | 心理系 |
| Keywords: | Hippocampus;infiltrative non-GBM gliomas;neurocognitive functions;radiation therapy |
| Date: | 2022-03 |
| Issue Date: | 2022-08-23 15:09:02 (UTC+8) |
| Abstract: | Infiltrative non-GBM gliomas are common primary intracranial malignancies, and postoperative adjuvant radiotherapy is recommended for most adult patients diagnosed with this disease to enhance local control and prolong intracranial progression-free survival (PFS). However, RT-related neurocognitive function (NCF) consequences should not be ignored. Early neurocognitive decline principally includes episodic memory, associated significantly with functions of the hippocampus. This prospective study aims to investigate the impact of adjuvant brain irradiation on neurocognitive performances and relevant oncological outcomes.Twenty-five patients with intracranial infiltrative non-GBM gliomas were enrolled when postoperative adjuvant RT was recommended. All recruited patients should receive baseline brain magnetic resonance imaging, and neuropsychological assessments before and 4 months after the RT course. A battery of neuropsychological measures, mainly including executive functions, memory, psychomotor speed and visuoconstructive ability, was used to evaluate NCFs of interest.Analyzing the delta values between post-irradiation and baseline NCF scores, we observed a robust trend reflecting cognitive stabilization rather than deterioration in almost all NCF. Both verbal and visual memory functions exhibited significant differences in the corresponding scaled scores (Z = -2.722, p = .006, regarding verbal memory; Z = -2.246, p = .025, concerning non-verbal memory). Moreover, patients` neuropsychological performances associated with psychomotor speed and executive functions also disclosed a tendency toward stabilization/improvement.This prospective study demonstrated that patients with infiltrative non-GBM exhibited a marked tendency toward neurocognitive stabilization after receiving postoperative adjuvant RT. Clinical trial registration: Trial Registration with ClinicalTrials.gov identifier: NCT03534050. |
| Relation: | Applied Neuropsychology: Adult |
| Data Type: | article |
| DOI 連結: | https://doi.org/10.1080/23279095.2022.2048830 |
| DOI: | 10.1080/23279095.2022.2048830 |
| Appears in Collections: | [心理學系] 期刊論文
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