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    政大機構典藏 > 資訊學院 > 資訊科學系 > 學位論文 >  Item 140.119/150172
    Please use this identifier to cite or link to this item: https://nccur.lib.nccu.edu.tw/handle/140.119/150172

    Title: 基於三級交聯圖與表觀基因特徵分群對基因組切割
    Genome segmentation based on the embedding of chromosome contact and ChIP-seq networks
    Authors: 張修誠
    Chang, Hsiu-Cheng
    Contributors: 張家銘
    Chang, Jia-Ming
    Chang, Hsiu-Cheng
    Keywords: 高通量染色體捕獲技術
    Date: 2024
    Issue Date: 2024-03-01 13:42:29 (UTC+8)
    Abstract: 高通量染色體捕獲技術(Hi-C)的全基因組染色體接觸矩陣可用於研究染色體三級結構組織,組織由大至小可分為隔間、子隔間以及拓撲結構域。本研究透過高通量染色體捕獲技術和染色質免疫沉澱-測序(ChIP-seq)兩項技術獲得了基因組的空間結構和基因間相互作用的重要信息,應用圖論的節點嵌入和資訊融合的技術並分群,以高解析度資料處理不同尺度的組織分區,提供更全面的基因組切割分析,透過降維視覺化和量化分析結果呈現有效找出基因體區分。
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    2. Dekker, Job, et al. "Capturing chromosome conformation." Science 295.5558 (2002): 1306-1311.
    3. Van Berkum, Nynke L., et al. "Hi-C: a method to study the three-dimensional architecture of genomes." JoVE (Journal of Visualized Experiments) 39 (2010): e1869.
    4. Johnson, David S., et al. "Genome-wide mapping of in vivo protein-DNA interactions." Science 316.5830 (2007): 1497-1502.
    5. Illumina et al.Pub. No. 770-2007-007 Current as of 26 November 2007. Whole-Genome Chromatin IP Sequencing (ChIP-seq).
    6. Rao, Suhas SP, et al. "A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping." Cell 159.7 (2014): 1665-1680.
    7. Peifer, Martin, et al. "Telomerase activation by genomic rearrangements in high-risk neuroblastoma." Nature 526.7575 (2015): 700-704.
    8. Ashoor, Haitham, et al. "Graph embedding and unsupervised learning predict genomic sub-compartments from HiC chromatin interaction data." Nature communications 11.1 (2020): 1173.
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    Description: 碩士
    Source URI: http://thesis.lib.nccu.edu.tw/record/#G0110753165
    Data Type: thesis
    Appears in Collections:[資訊科學系] 學位論文

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