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    政大機構典藏 > 理學院 > 心理學系 > 期刊論文 >  Item 140.119/156572


    Please use this identifier to cite or link to this item: https://nccur.lib.nccu.edu.tw/handle/140.119/156572


    Title: Investigating the inhibition deficits in male patients undergoing methadone-maintained treatment with cognitive modeling
    以認知模擬檢視男性美沙酮替代療法患者之抑制缺損
    Authors: 楊立行;林怡彤;胡中凡;陳喬琪;許文耀
    Yang, Lee-Xieng;Lin, Yi-Tung;Hu, Jon-Fan;Chen, Chiao-Chicy;Hsu, Wen-Yau
    Contributors: 心理系
    Keywords: Cognitive modeling;Inhibition deficit;Instrumental learning;Methadone substitution or maintenance treatment;Modified Go/No-Go task
    工具性學習;抑制缺損;美沙酮替代療法;修改版Go/No-Go測驗;認知模擬
    Date: 2024-12
    Issue Date: 2025-04-14 09:50:48 (UTC+8)
    Abstract: Previous literature assessing inhibition deficits in patients undergoing methadone maintenance treatment (MMT) using the Go/No-Go task has overlooked the unbalanced design in which participants learn behavioral inhibition and behavioral approach. This study aims to examine the extent of behavioral deficits in patients undergoing MMT when response (go/nogo response) and valence (reward for correct response/punishment for incorrect response) are orthogonalized in the modified Go/No-Go task. Fifty former heroin misusers were recruited from a city hospital, along with 30 male controls, and were assessed using Raven’s Standard Progressive Matrices, Beck Depression InventoryII, Beck Anxiety Inventory, and the modified Go/No-Go task. Cognitive modeling was conducted to investigate the underlying processes. The results showed that patients undergoing MMT had significantly higher error rates in the nogo-to-win trials than in the go-to-win trials, while there was no significant difference in the control group. The learning rate in nogo-to-win trials of patients undergoing MMT was not only slower than that in controls but also slower than patients’ undergoing MMT own learning rate in go-to-win trials. The findings suggest that the patients undergoing MMT showed an inhibition deficit, which might be relevant to a poorer learning rate for behavioral inhibition.
    過去研究顯示，以 Go/No-Go 測驗來檢視美沙酮替代療法的患者（patients undergoing methadone-maintained treatment）之認知缺損時，忽略了此測驗中學習行為抑制與行為趨近的條件是不對等的。為此，本研究設計一個修 改版的 Go/No-Go 測驗，不論是 go 反應還是 nogo 反應，當反應為正確時皆得到酬賞，反應錯誤時皆得到處罰。在 此反應與價性正交化（orthogonalized）的情況下，檢視美沙酮替代療法患者的抑制缺損情況。本研究於台北市立聯 合醫院招募 50 位正在接受美沙酮替代療法的男性海洛因成癮患者，以及 30 位從網路招募的男性對照組。參與者 會接受瑞文氏標準圖形推理測驗、貝克憂鬱量表、貝克焦慮量表，以及修改版 Go/No-Go 測驗。為了檢視於修改版 Go/No-Go 測驗中的認知運作歷程，本研究使用認知模擬來分析行為資料。本研究結果顯示，美沙酮替代療法患者 於 nogo-to-win 嘗試次中的錯誤率顯著高於 go-to-win 嘗試次之錯誤率；對照組中則沒有這樣的顯著差異。美沙酮替 代療法患者於 nogo-to-win 嘗試次中的學習速率，不僅顯著低於對照組，也顯著低於美沙酮替代療法患者自身於 goto-win 嘗試次中的學習速率。本研究的結果意涵著美沙酮替代療法患者具有抑制缺損，這可能是因為其學習行為抑 制上的學習速率較差所帶來的影響。
    Relation: 中華心理學刊, Vol.66, No.4, pp.453-467
    Data Type: article
    DOI 連結: https://doi.org/10.6129/CJP.202412_66(4).0003
    DOI: 10.6129/CJP.202412_66(4).0003
    Appears in Collections:[心理學系] 期刊論文

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