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| Title: | 以觀看喜劇電影探討大腦接受自然刺激時的神經代謝變化
Brain Metabolic Dynamics in Response to Naturalistic Stimuli Presented by Watching Comedy Movie |
| Authors: | 蔡尚岳;張卿卿 |
| Contributors: | 應物所 |
| Date: | 2018-01 |
| Issue Date: | 2025-05-29 11:57:02 (UTC+8) |
| Abstract: | 目前非侵入式的影像方法 (功能性磁振造影以及腦電圖)，已廣泛的被用來探討大腦認知功能，然而，過去數十年的研究，主要都是利用人工處理簡化後的刺激材料，來進行腦功能刺激，目前已有一些證據指出大腦是傾向處理複雜的自然刺激方式，因此開始有許多研究傾向運用自然刺激的方式，例如:觀看電影、電視或聆聽音樂片段，來探討大腦功能，這種方式也較適合用來探討跟日常生活相關的複雜認知功能，目前有研究發現，受試者在觀看同樣電影片段時的神經活動(腦電圖與功能性磁振造影)是有相關性的，但即使有一些影像方法的結果，目前對於神經活動所引起的神經代謝變化的研究，例如神經傳導物質的變化，是很缺乏的，因此，我們這個計畫主要透過先進的磁共振頻譜技術，量測大腦兩種主要的神經傳導物質，γ-氨基丁酸與谷氨酸，在看喜劇電影片段的過程中的變化，我們預計收取80 個正常受試者的磁共振頻譜資料，用來探討三個主要的目標，一，比較這兩種神經傳導物質在觀看電影前後的改變；二，探討是否觀看電影時的代謝變化，是否如如神經反應一般，可以顯示出受試者間的關聯性；三，將代謝的結果跟另外兩個子計劃觀察到的神經活動連結，用以解釋大腦在以自然電影刺激時的活動機制。
With the development of non-invasive imaging methods, including functional magnetic resonance imaging (fMRI), electroencephalography (EEG), we have gained a lot of knowledge about how human brain works to complete tasks and cognition. However, in the last two decades, most fMRI and EEG/MEG studies use artificial and simplified stimuli and tasks to localize and to characterize functional areas. With converging evidences suggest that the human brain has evolved to deal with complex naturalistic stimuli and to elicit neuronal responses more reliably, there is an emerging trend of using naturalistic stimuli, including movies, TV shows, and musical pieces, to study human brain function. This experimental technique has been suggested to be more appropriate to probe the neuronal responses related to complex cognitive processes common in our daily life such as movie watching. Inter subject correlation of neuro-activity of EEG and BOLD under natural stimuli has been investigated. However, there is lack of understanding in the neuro-chemical response to the naturalistic stimuli and how activation of brain can cause underlying neurotransmitters in these activated regions to release and accumulate in the brain. Therefore, inspired by these imaging findings, we propose to use advanced MRS method to investigate brain metabolic change of two important neurotransmitters during watching comedy movie clips. An advanced MRS method, called MEGA-PRESS, is used to probe two major neurotransmitter, GABA and Glu, in the brain while provide sufficient temporal resolution to catch dynamic change of these two neurotransmitters during watching a comedy movie. In this two years project, we propose to collect MRS data from a total of 80 healthy subjects to achieve tow specific aims. (1) To compare the level of these two neurotransmitters before and after watching comedy movies. (2) To reveal the inter-subject correlated metabolic response during watching comedy movie at the same brain regions showing inter-subject correlated brain activity. (3) To bridge the neuroimaging evidence obtained using different imaging modality (e.g., the EEG from the sub-project 3 and high resolution fMRI from the sub-project 1) for integrating the metabolic-neuro-vascular coupling underlying comedy movie watching. |
| Relation: | 科技部, MOST105-2420-H004-003-MY2, 105.01-106.12 |
| Data Type: | report |
| Appears in Collections: | [應用物理研究所 ] 國科會研究計畫
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