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| Title: | 經顱直流電刺激對皮質區神經傳導物質的影響
The effect of Transcranial Direct Current Stimulation on the cortical neurotransmitter level |
| Authors: | 張郁傑
Chang, Yu-Chieh |
| Contributors: | 蔡尚岳
Tsai, Shang-Yueh
張郁傑
Chang, Yu-Chieh |
| Keywords: | 經顱直流電刺激
γ-胺基丁酸
磁共振頻譜
Transcranial Direct Current Stimulation
Gamma-aminobutyric acid
Magnetic resonance spectroscopy |
| Date: | 2025 |
| Issue Date: | 2025-06-02 14:43:08 (UTC+8) |
| Abstract: | 本研究旨在探討經顱直流電刺激(tDCS)對成人大腦γ-胺基丁酸(GABA)濃度的短期和長期之影響。隨著tDCS在神經科學領域中的廣泛應用，了解其對大腦神經傳導物質的影響至關重要。研究中，陽極電極放置於左腦初級運動皮層，陰極放置於右腦前額葉皮質，並使用磁共振頻譜(MRS)技術掃描大腦，以觀察GABA濃度的變化，MRS掃描數據通過MEGA-PRESS編輯序列獲得，隨後使用MATLAB內的Gannet套件進行MRS數據處理和分析的步驟。受試者被分為陽極刺激組和假刺激組，而陽極刺激組還進一步細分為Top組和Bottom組，Top和Bottom組的區別在於電流的流動方向，雖然兩組的陽極電極都放置於左側初級運動皮層(M1)，但電線的佈置方式有所不同，Top組的電線安排使得電流從上方流向大腦皮層表層，而Bottom組的電線安排則使電流從下方流向大腦皮層，目的是要探討不同電流流向的效果。研究結果顯示，tDCS在短期內顯著提升了GABA濃度，尤其在Top組和右側大腦中效果更為顯著。然而，長期觀察顯示，GABA濃度逐漸回到初始水平，暗示短期影響並未持續，這些發現為未來tDCS應用的研究提供了重要參考。
This study aims to investigate the short-term and long-term effects of transcranial direct current stimulation (tDCS) on gamma-aminobutyric acid (GABA) concentrations in the adult brain. With the extensive application of tDCS in the field of neuroscience, understanding its impact on neurotransmitter levels is crucial. In this research, the anodal electrode was placed over the left primary motor cortex (M1), while the cathodal electrode was positioned on the right prefrontal cortex. Magnetic resonance spectroscopy (MRS) was employed to measure changes in GABA concentrations, with MRS data acquired using the MEGA-PRESS editing sequence and analyzed through the Gannet toolbox in MATLAB. Participants were divided into anodal stimulation and sham groups, and the anodal stimulation group was further subdivided into Top and Bottom groups. The distinction between the Top and Bottom groups was based on the direction of current flow.While the anodal electrode in both subgroups was placed on the left M1, the electrode wire arrangement differed: the Top group directed the current from above the cortical surface, and the Bottom group directed it from below. The goal was to explore the effects of varying current directions. Results revealed that tDCS significantly increased GABA concentrations in the short term, particularly in the Top group and in the right hemisphere. However, long-term observations indicated that GABA levels gradually returned to baseline, suggesting that short-term effects were not sustained. These findings provide critical insights for future research into tDCS applications. |
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| Description: | 碩士
國立政治大學
應用物理研究所
110755007 |
| Source URI: | http://thesis.lib.nccu.edu.tw/record/#G0110755007 |
| Data Type: | thesis |
| Appears in Collections: | [應用物理研究所 ] 學位論文
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