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    题名: Identifying Chromosomal Fragile Sites from a Hierarchical-clustering Point of view
    作者: 侯家鼎;江振東;戴政
    Hou, Chia-Ding;Chiang, Jengtung;John Jen Tai
    关键词: Equiprobability model;Fragile site;Hierarchical clustering;Multiple hypothesis testing;Proportional probability model
    日期: 2001-06
    上传时间: 2008-12-19 14:51:20 (UTC+8)
    摘要: Identification of fragile sites is a way to investigate the genetic abnormalities that are the hallmark of cancer and play an important role in carcinogenesis. Manifestation of nonrandom breakage at a chromosome band is an essential criterion for determination of the fragility of the band. In this article, a new detection procedure is proposed. This new procedure takes the relationship of one site with the others into consideration and can be applied to tests of the randomness of breakpoints under either the proportional probability model (PPM) or the equiprobability model (EPM). The procedure can form a grouping structure that classifies all sites into several clusters. It is applied to identification of fragile sites for a real data set for Chinese patients with colorectal carcinoma for illustration of the proposed method.
    關聯: Biometrics, 57(2), 435-440
    数据类型: article
    显示于类别:[統計學系] 期刊論文

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