政大機構典藏-National Chengchi University Institutional Repository(NCCUR):Item 140.119/19804

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政大機構典藏 > 理學院 > 心理學系 > 期刊論文 > Item 140.119/19804

Please use this identifier to cite or link to this item: https://nccur.lib.nccu.edu.tw/handle/140.119/19804

Title:	Place conditioning and neurochemical responses elicited by the aftereffect of acute stressor exposure involving an elevated stand
Authors:	Shen, Ying-Ling;Chen, Jin-Chung;Liao, Ruey-Ming;廖瑞銘
Contributors:	國立政治大學心理學系
Keywords:	Inescapable stress;Dopamine;DOPAC;Medial prefrontal cortex;Nucleus accumbens;HPLC
Date:	2011
Issue Date:	2008-12-29 15:33:42 (UTC+8)
Abstract:	Acute exposure to an elevated stand has been used as an inescapable mild stressor for rats. The present study examined the effects of this stressor using a place conditioning behavioral test and neurochemical assays of dopamine and its metabolite, 3,4-dihydroxyphenylacetic acid (DOPAC), in the medial prefrontal cortex and nucleus accumbens. The behavioral data showed that a conditioned place preference was formed as an aftereffect of the elevated stand stressor. In a separate experiment, neurochemical assay showed an immediate increase of dopamine in the nucleus accumbens after 30min exposure to the elevated stand stressor. In addition, the DOPAC content in the nucleus accumbens was significantly increased at 30min after this stressor. No significant change in dopamine or DOPAC levels in the medial prefrontal cortex was detected for up to 60min after stressor manipulation. These results suggest that an increase in dopamine activity in the nucleus accumbens is involved in the development of conditioned place preference elicited by the aftereffects of the elevated stand stressor.
Relation:	Neuroscience Letters, 504, 156-159
Data Type:	article
DOI 連結:	http://dx.doi.org/10.1016/j.neulet.2011.09.022
DOI:	10.1016/j.neulet.2011.09.022
Appears in Collections:	[心理學系] 期刊論文

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