| Reference: | Anastasi A, Erspamer V, Bucci M (1971) Isolation and structure of bombesin and alytesin, 2 analogous active peptides from the skin of the European amphibians Bombina and Alytes. Experientia 27(2):166-167.
Andrew D, Craig AD (2001) Spinothalamic lamina I neurons selectively sensitive to histamine: a central neural pathway for itch. Nat Neurosci 4(1):72-77.
Bailey PL, Rhondeau S, Schafer PG, Lu JK, Timmins BS, Foster W, Pace NL, Stanley TH (1993) Dose-response pharmacology of intrathecal morphine in human volunteers. Anesthesiology 79(1):49-59.
Barrett AC, Cook CD, Terner JM, Roach EL, Syvanthong C, Picker MJ (2002) Sex and rat strain determine sensitivity to kappa opioid-induced antinociception. Psychopharmacology (Berl) 160(2):170-81.
Bergasa NV (2008) Update on the treatment of the pruritus of cholestasis. Clin Liver Dis 12(1):219-234.
Bossut D, Frenk H, Mayer DJ (1988) Is substance P a primary afferent neurotransmitter for nociceptive input? II. Spinalization does not reduce and intrathecal morphine potentiates behavioral responses to substance P. Brain Res 455(2):232-239.
Butelman ER, Ko MC, Traynor JR, Vivian JA, Kreek MJ, Woods JH (2001) GR89,696: a potent kappa-opioid agonist with subtype selectivity in rhesus monkeys. J Pharmacol Exp Ther 298(3):1049-1059.
Butelman ER, Negus SS, Ai Y, de Costa BR, Woods JH (1993) Kappa opioid antagonist effects of systemically administered nor-binaltorphimine in a thermal antinociception assay in rhesus monkeys. J Pharmacol Exp Ther 267(3):1269-1276.
Chaney MA (1995) Side effects of intrathecal and epidural opioids. Can J Anaesth 42(10):891-903.
Chen X, McClatchy DB, Geller EB, Tallarida RJ, Adler MW (2005) The dynamic relationship between mu and kappa opioid receptors in body temperature regulation. Life Sci 78(4):329-33.
Clark JA, Liu L, Price M, Hersh B, Edelson M, Pasternak GW (1989) Kappa opiate receptor multiplicity: evidence for two U50,488-sensitive kappa 1 subtypes and a novel kappa 3 subtype. J Pharmacol Exp Ther 251(2):461-468.
Cowan A, Gmerek DE (1986) In vivo studies on kappa opioid receptors. Trends Pharmacol Sci 7:69–72.
Cousins MJ, Mather LE (1984) Intrathecal and epidural administration of opioids. Anesthesiology 61(3):276-310.
Davidson S, Zhang X, Yoon CH, Khasabov SG, Simone DA, Giesler GJ Jr (2007) The itch-producing agents histamine and cowhage activate separate populations of primate spinothalamic tract neurons. J Neurosci 27(37):10007-10014.
De Castro-Costa M, Gybels J, Kupers R, Van Hees J (1987) Scratching behaviour in arthritic rats: a sign of chronic pain or itch? Pain 29(1):123-131.
Drzezga A, Darsow U, Treede RD, Siebner H, Frisch M, Munz F, Weilke F, Ring J, Schwaiger M, Bartenstein P (2001) Central activation by histamine-induced itch: analogies to pain processing: a correlational analysis of O-15 H2O positron emission tomography studies. Pain 92(1-2):295-305.
Frenk H, Bossut D, Urca G, Mayer DJ (1988) Is substance P a primary afferent neurotransmitter for nociceptive input? I. Analysis of pain-related behaviors resulting from intrathecal administration of substance P and 6 excitatory compounds. Brain Res 455(2):223-231.
Ganesh A, Maxwell LG (2007) Pathophysiology and management of opioid-induced pruritus. Drugs 67(16):2323-2333.
Glick SD, Maisonneuve IM, Raucci J, Archer S (1995) Kappa opioid inhibition of morphine and cocaine self-administration in rats. Brain Res 681(1-2):147-152.
Gmerek DE, Cowan A (1983a) An animal model for preclinical screening of systemic antipruritic agents. J Pharmacol Methods 10(2):107-112.
Gmerek DE, Cowan A (1983b) Studies on bombesin-induced grooming in rats. Peptides 4(6):907-913.
Gmerek DE, Dykstra LA, Woods JH (1987) Kappa opioids in rhesus monkeys. III. Dependence associated with chronic administration. J Pharmacol Exp Ther 242(2):428-436.
Gogas KR, Cho HJ, Botchkina GI, Levine JD, Basbaum AI (1996) Inhibition of noxious stimulus-evoked pain behaviors and neuronal fos-like immunoreactivity in the spinal cord of the rat by supraspinal morphine. Pain 65(1):9-15.
Gogas KR, Presley RW, Levine JD, Basbaum AI (1991) The antinociceptive action of supraspinal opioids results from an increase in descending inhibitory control: correlation of nociceptive behavior and c-fos expression. Neuroscience 42(3):617-628.
Goldstein A, Naidu A (1989) Multiple opioid receptors: ligand selectivity profiles and binding site signatures. Mol Pharmacol 36(2):265-272.
Heishman SJ, Stitzer ML, Bigelow GE, Liebson IA (1989) Acute opioid physical dependence in postaddict humans: naloxone dose effects after brief morphine exposure. J Pharmacol Exp Ther 248(1):127-134.
Hiramatsu M, Inoue K, Ambo A, Sasaki Y, Kameyama T (2001) Long-lasting antinociceptive effects of a novel dynorphin analogue, Tyr-D-Ala-Phe-Leu-Arg psi (CH(2)NH) Arg-NH(2), in mice. Br J Pharmacol 132(8):1948-1956.
Hsieh JC, Hägermark O, Ståhle-Bäckdahl M, Ericson K, Eriksson L, Stone-Elander S, Ingvar M (1994) Urge to scratch represented in the human cerebral cortex during itch. J Neurophysiol 72(6):3004-3008.
Ikoma A, Steinhoff M, Ständer S, Yosipovitch G, Schmelz M (2006) The neurobiology of itch. Nat Rev Neurosci 7(7):535-547.
Inan S, Cowan A (2006) Nalfurafine, a kappa opioid receptor agonist, inhibits scratching behavior secondary to cholestasis induced by chronic ethynylestradiol injections in rats. Pharmacol Biochem Behav 85(1):39-43.
Inoue M, Shimohira I, Yoshida A, Zimmer A, Takeshima H, Sakurada T, Ueda H (1999) Dose-related opposite modulation by nociceptin/orphanin FQ of substance P nociception in the nociceptors and spinal cord. J Pharmacol Exp Ther 291(1):308-313.
Jensen RT, Battey JF, Spindel ER, Benya RV (2008) International Union of Pharmacology. LXVIII. Mammalian bombesin receptors: Nomenclature, distribution, pharmacology, signaling, and functions in normal and disease states. Pharmacol Rev 60:1-42.
Jin CL, Yang LX, Wu XH, Li Q, Ding MP, Fan YY, Zhang WP, Luo JH, Chen Z (2005) Effects of carnosine on amygdaloid-kindled seizures in Sprague-Dawley rats. Neuroscience 135(3):939-947
Kamei J, Nagase H (2001) Norbinaltorphimine, a selective kappa-opioid receptor antagonist, induces an itch-associated response in mice. Eur J Pharmacol 418(1-2): 141-145.
Kishioka S, Paronis C A, Woods J H (2000) Acute dependence on, but not tolerance to heroin and morphine as measured by respiratory effects in rhesus monkeys. Eur J Pharmacol 398(1):121-130.
Kjellberg F, Tramèr MR (2001) Pharmacological control of opioid-induced pruritus: a quantitative systematic review of randomized trials. Eur J Anaesthesiol 18(6):346-357.
Ko MC, Butelman ER, Traynor JR, Woods JH (1998) Differentiation of kappa opioid agonist-induced antinociception by naltrexone apparent pA2 analysis in rhesus monkeys. J Pharmacol Exp Ther 285(2):518-526.
Ko MC, Husbands SM (2009) Effects of atypical κ-opioid receptor agonists on intrathecal morphine-induced itch and analgesia in primates. J Pharmacol Exp Ther 328(1):193-200.
Ko MC, Johnson MD, Butelman ER, Willmont KJ, Mosberg HI, Woods JH (1999a) Intracisternal nor-binaltorphimine distinguishes central and peripheral kappa-opioid antinociception in rhesus monkeys. J Pharmacol Exp Ther 291(3):1113-1120.
Ko MC, Johnson MD, Choo KS, Song MS, Chang D, Naughton NN, Woods JH (1999b) An experimental itch model in rats: Characterization of intracisternal morphine-induced scratching and antinociception. FASEB J 13:622.611.
Ko MC, Lee H, Song MS, Sobczyk-Kojiro K, Mosberg HI, Kishioka S, Woods JH, Naughton NN (2003a) Activation of κ-opioid receptors inhibits pruritus evoked by subcutaneous or intrathecal administration of morphine in monkeys. J Pharmacol Exp Ther 305:173–179.
Ko MC, Lee H, Traynor JR, Woods JH, Naughton NN (2003b) Differential antinociceptive effects of intrathecally administered opioid agonists selective for mu, kappa and delta opioid receptors in monkeys. Drug Alcohol Depend 69 (Suppl):87.
Ko MC, Naughton NN (2000) An experimental itch model in monkeys : Characterization of intrathecal morphine-induced scratching and antinociception. Anesthesiology 92(3):795–805.
Ko MC, Naughton NN (2009) Antinociceptive effects of nociceptin/orphanin FQ administered intrathecally in monkeys. J Pain 10(5):509-516.
Ko MC, Song MS, Edwards T, Lee H, Naughton NN (2004) The role of central mu opioid receptors in opioid-induced itch in primates. J Pharmacol Exp Ther 310(1):169-176.
Krajnik M, Zylicz Z (2001) Understanding pruritus in systemic disease. J Pain Symptom Manage 21(2):151-168.
Kulkosky PJ, Gibbs J, Smith GP (1982) Behavioral effects of bombesin administration in rats. Physiol Behav 28(3):505-512.
Kuraishi Y, Yamaguchi T, Miyamoto T (2000) Itch-scratch responses induced by opioids through central mu opioid receptors in mice. J Biomed Sci 7(3):248-252.
Kuzmin AV, Semenova S, Gerrits MA, Zvartau EE, Van Ree JM (1997) Kappa-opioid receptor agonist U50,488H modulates cocaine and morphine self-administration in drug-naive rats and mice. Eur J Pharmacol 321(3):265-271.
Lee H, Naughton NN, Woods JH, Ko MC (2003) Characterization of scratching responses in rats following centrally administered morphine or bombesin. Behav Pharmacol 14(7):501-508.
Lee H, Naughton NN, Woods JH, Ko MC (2007) Effects of butorphanol on morphine-induced itch and analgesia in primates. Anesthesiology 107(3):478-485.
Makulska-Nowak HE, Gumułka SW, Lipkowski AW, Rawa MA (2001) Effects of endomorphin-2 on arterial blood pressure and pain threshold in spontaneously hypertensive rats and modification of these effects by beta-funaltrexamine and nor-binaltorphimine. Life Sci 69(5):581-589.
Manenti L, Tansinda P, Vaglio A (2009) Uraemic pruritus: clinical characteristics, pathophysiology and treatment. Drugs 69(3):251-263.
Margolis EB, Lock H, Chefer VI, Shippenberg TS, Hjelmstad GO, Fields HL (2006) Kappa opioids selectively control dopaminergic neurons projecting to the prefrontal cortex. Proc Natl Acad Sci U S A 103(8):2938-2942
McNally GP, Akil H (2002) Role of corticotropin-releasing hormone in the amygdala and bed nucleus of the stria terminalis in the behavioral, pain modulatory, and endocrine consequences of opiate withdrawal. Neuroscience 112(3):605-617.
Miaskowski C, Taiwo YO, Levine JD (1991) Contribution of supraspinal mu- and delta-opioid receptors to antinociception in the rat. Eur J Pharmacol 205(3):247-252.
Minami M, Satoh M (1995) Molecular biology of the opioid receptors: structures, functions and distributions. Neurosci Res 23(2):121-145.
Mochizuki H, Tashiro M, Kano M, Sakurada Y, Itoh M, Yanai K (2003) Imaging of central itch modulation in the human brain using positron emission tomography. Pain 105(1-2):339-346.
Morgan MM, Fossum EN, Stalding BM, King MM (2006) Morphine antinociceptive potency on chemical, mechanical, and thermal nociceptive tests in the rat. J Pain 7(5):358-366.
Moochhala SM, Sawynok J (1984) Hyperalgesia produced by intrathecal substance P and related peptides: desensitization and cross desensitization. Br J Pharmacol 82(2):381-388.
Moody TW, Merali Z (2004) Bombesin-like peptides and associated receptors within the brain: distribution and behavioral implications. Peptides 25(3):511-520.
Negus SS, Gatch MB, Mello NK, Zhang X, Rice K (1998) Behavioral effects of the delta-selective opioid agonist SNC80 and related compounds in rhesus monkeys. J Pharmacol Exp Ther 286(1):362-375.
O`Donohue TL, Massari VJ, Pazoles CJ, Chronwall BM, Shults CW, Quirion R, Chase TN, Moody TW (1984) A role for bombesin in sensory processing in the spinal cord. J Neurosci 4:2956-2962
Orzechowski RF, Currie DS, Valancius CA (2005) Comparative anticholinergic activities of 10 histamine H1 receptor antagonists in two functional models. Eur J Pharmacol 506(3):257-264
Osifo NG (1989) Mechanisms of enhanced pruritogenicity of chloroquine among patients with malaria: a review. Afr J Med Med Sci 18(2):121-129.
Palmer CM, Emerson S, Volgoropolous D, Alves D (1999) Dose-response relationship of intrathecal morphine for postcesarean analgesia. Anesthesiology 90:437-444
Pan ZZ (1998) Mu-Opposing actions of the kappa-opioid receptor. Trends Pharmacol Sci 19(3):94-98
Panula P, Hadjiconstantinou M, Yang HY, Costa E (1983) Immunohistochemical localization of bombesin/gastrin-releasing peptide and substance P in primary sensory neurons. J Neurosci 3:2021-2029.
Raffaeli W, Marconi G, Fanelli G, Taddei S, Borghi GB, Casati A (2006) Opioid-related side-effects after intrathecal morphine: a prospective, randomized, double-blind dose-response study. Eur J Anaesthesiol 23(7):605-610.
Rawal N, Schött U, Dahlström B, Inturrisi CE, Tandon B, Sjöstrand U, Wennhager M (1986) Influence of naloxone infusion on analgesia and respiratory depression following epidural morphine. Anesthesiology 64(2):194-201.
Rothman RB (1992) A review of the role of anti-opioid peptides in morphine tolerance and dependence. Synapse 12(2):129-138.
Sakurada T, Katsuyama S, Sakurada S, Inoue M, Tan-No K, Kisara K, Sakurada C, Ueda H, Sasaki J (1999) Nociceptin-induced scratching, biting and licking in mice: involvement of spinal NK1 receptors. Br J Pharmacol 127(7):1712-1718.
Schmelz M, Schmidt R, Bickel A, Handwerker HO, Torebjork HE (1997) Specific C-receptors for itch in human skin. J Neurosci 17:8003–8008.
Schulz DW, Kalivas PW, Nemeroff CB, Prange AJ Jr (1984) Bombesin-induced locomotor hyperactivity: evaluation of the involvement of the mesolimbic dopamine system. Brain Res 304(2):377-382.
Shannon HE, Lutz EA (2002) Comparison of the peripheral and central effects of the opioid agonists loperamide and morphine in the formalin test in rats. Neuropharmacology 42(2):253-261.
Simmons ML, Chavkin C (1996) k-Opioid receptor activation of a dendrotoxin -sensitive potassium channel mediates presynaptic inhibition of mossy fiber neurotransmitter release. Mol Pharmacol 50(1):80-85.
Simonin F, Gavériaux-Ruff C, Befort K, Matthes H, Lannes B, Micheletti G, Mattéi MG, Charron G, Bloch B, Kieffer B (1995) kappa-Opioid receptor in humans: cDNA and genomic cloning, chromosomal assignment, functional expression, pharmacology, and expression pattern in the central nervous system. Proc Natl Acad Sci U S A 92(15):7006-7010.
Sites BD, Beach M, Gallagher JD, Jarrett RA, Sparks MB, Lundberg CJ (2004) A single injection ultrasound-assisted femoral nerve block provides side effect-sparing analgesia when compared with intrathecal morphine in patients undergoing total knee arthroplasty. Anesth Analg 99(5):1539-1543.
Spanagel R, Herz A, Shippenberg TS (1992) Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway. Proc Natl Acad Sci U S A 89(6):2046-2050.
Stefano GB, Goumon Y, Casares F, Cadet P, Fricchione GL, Rialas C, Peter D, Sonetti D, Guarna M, Welters ID, Bianchi E (2000) Endogenous morphine. Trends Neurosci 23(9):436-442.
Sterious SN, Walker EA (2003) Potency differences for D-Phe-Cys-Tyr-D-Trp-Arg- Thr-Pen-Thr-NH2 as an antagonist of peptide and alkaloid micro-agonists in an antinociception assay. J Pharmacol Exp Ther 304(1):301-309.
Sun YG, Chen ZF (2007) A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord. Nature 448(7154):700-703.
Szarvas S, Harmon D, Murphy D (2003) Neuraxial opioid-induced pruritus: a review. J Clin Anesth 15(3):234-239.
Takemori AE, Loh HH, Lee NM (1992) Suppression by dynorphin A-(1-13) of the expression of opiate withdrawal and tolerance in mice. Eur J Pharmacol 221(2-3):223-226.
Terner JM, Lomas LM, Smith ES, Barrett AC, Picker MJ (2003) Pharmacogenetic analysis of sex differences in opioid antinociception in rats. Pain 106(3):381-391.
Thomas DA, Hammond DL (1995) Microinjection of morphine into the rat medullary dorsal horn produces a dose-dependent increase in facial scratching. Brain Res 695(2):267-270.
Thomas DA, Williams GM, Iwata K, Kenshalo DR Jr, Dubner R (1992) Effects of central administration of opioids on facial scratching in monkeys. Brain Res 585:315-317.
Togashi Y, Umeuchi H, Okano K, Ando N, Yoshizawa Y, Honda T, Kawamura K, Endoh T, Utsumi J, Kamei J, Tanaka T, Nagase H (2002) Antipruritic activity of the kappa-opioid receptor agonist, TRK-820. Eur J Pharmacol 435(2-3):259-264.
Tohda C, Yamaguchi T, Kuraishi Y (1997) Intracisternal injection of opioids induces itch-associated response through mu-opioid receptors in mice. Jpn J Pharmacol 74(1):77-82.
Umeuchi H, Togashi Y, Honda T, Nakao K, Okano K, Tanaka T, Nagase H (2003) Involvement of central mu-opioid system in the scratching behavior in mice, and the suppression of it by the activation of kappa-opioid system. Eur J Pharmacol 477(1):29-35.
Wagner JJ, Terman GW, Chavkin C (1993) Endogenous dynorphins inhibit excitatory neurotransmission and block LTP induction in the hippocampus. Nature 363(6428):451-454.
Walker EA, Makhay MM, House JD, Young AM (1994) In vivo apparent pA2 analysis for naltrexone antagonism of discriminative stimulus and analgesic effects of opiate agonists in rats. J Pharmacol Exp Ther 271(2):959-968.
Wang JJ, Ho ST, Tzeng JI (1998) Comparison of intravenous nalbuphine infusion versus naloxone in the prevention of epidural morphine-related side effects. Reg Anesth Pain Med 23(5):479-484.
Waxler B, Dadabhoy ZP, Stojiljkovic L, Rabito SF (2005) Primer of postoperative pruritus for anesthesiologists. Anesthesiology 103(1):168-178.
Wikström B, Gellert R, Ladefoged SD, Danda Y, Akai M, Ide K, Ogasawara M, Kawashima Y, Ueno K, Mori A, Ueno Y (2005) Kappa-opioid system in uremic pruritus: multicenter, randomized, double-blind, placebo-controlled clinical studies. J Am Soc Nephrol 16(12):3742-3747.
Zadina JE, Martin-Schild S, Gerall AA, Kastin AJ, Hackler L, Ge LJ, Zhang X (1999) Endomorphins: novel endogenous mu-opiate receptor agonists in regions of high mu-opiate receptor density. Ann N Y Acad Sci 897:136-144.
Zhu Q, Wu DC, Zhou XP, Gong S, Cheng BC, Qin ZH, Reid PF, Yin QZ, Jiang XH (2008) Inhibitory effect of crotoxin on the pain-evoked discharge of neurons in thalamic parafascicular nucleus in rats. Toxicon 51(1):102-111.
Zukin RS, Eghbali M, Olive D, Unterwald EM, Tempel A (1988) Characterization and visualization of rat and guinea pig brain kappa opioid receptors: evidence for kappa 1 and kappa 2 opioid receptors. Proc Natl Acad Sci U S A 85(11):4061-4065. |
