政大機構典藏-National Chengchi University Institutional Repository(NCCUR):Item 140.119/70093
English  |  正體中文  |  简体中文  |  Post-Print筆數 : 27 |  全文笔数/总笔数 : 110097/141043 (78%)
造访人次 : 46425912      在线人数 : 531
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻


    请使用永久网址来引用或连结此文件: https://nccur.lib.nccu.edu.tw/handle/140.119/70093


    题名: Subordination stress alters alternative splicing of the Slo gene in tree shrew adrenals
    作者: 賴桂珍
    David P McCobb;Yuko Hara;Lai,Guey-Jen;Sahar F Mahmoud;Gabriele Flügge
    贡献者: 神科所
    关键词: Potassium channels;BK channels;Slo;HPA axis;Psychosocial stress;Alternative splicing;Steroids
    日期: 2003.01
    上传时间: 2014-09-23 12:26:25 (UTC+8)
    摘要: It was previously hypothesized that stress hormones regulate the alternative splicing of Slo potassium channels, thereby tuning the intrinsic excitability of adrenal chromaffin cells. Male tree shrews subjected to chronic stress by exposure to a dominant male develop robust symptoms with parallels to human depression. We report here that adrenals from males subjected to 4–6 weeks of subordination have a significantly smaller proportion of Slo transcripts with the optional STREX exon (STRess-axis regulated EXon) than unstressed male adrenals. Female adrenals (unstressed) had even lower levels than stressed males. These data suggest both behavioral regulation and sexual dimorphism in ion channel structure. We hypothesize that chromaffin cell excitability and sympathoadrenal function will be altered, and speculate that this may favor passive coping responses in subordinate males and females.
    關聯: Hormones and Behavior,43(1),180-186
    数据类型: article
    显示于类别:[神經科學研究所 ] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    180-186.pdf182KbAdobe PDF21006检视/开启


    在政大典藏中所有的数据项都受到原著作权保护.


    社群 sharing

    著作權政策宣告 Copyright Announcement
    1.本網站之數位內容為國立政治大學所收錄之機構典藏，無償提供學術研究與公眾教育等公益性使用，惟仍請適度，合理使用本網站之內容，以尊重著作權人之權益。商業上之利用，則請先取得著作權人之授權。
    The digital content of this website is part of National Chengchi University Institutional Repository. It provides free access to academic research and public education for non-commercial use. Please utilize it in a proper and reasonable manner and respect the rights of copyright owners. For commercial use, please obtain authorization from the copyright owner in advance.

    2.本網站之製作，已盡力防止侵害著作權人之權益，如仍發現本網站之數位內容有侵害著作權人權益情事者，請權利人通知本網站維護人員(nccur@nccu.edu.tw)，維護人員將立即採取移除該數位著作等補救措施。
    NCCU Institutional Repository is made to protect the interests of copyright owners. If you believe that any material on the website infringes copyright, please contact our staff(nccur@nccu.edu.tw). We will remove the work from the repository and investigate your claim.
    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈